Advances in Targeting Mitochondrial Sirtuins for Treatment of Metabolic Diseases Such as Type 2 Diabetes and Obesity
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 78
Special Issue Editors
Interests: metabolic diseases; mitochondrial sirtuins; type 2 diabetes; oxidative stress; obesity; adipogenesis; fat remodeling
Special Issue Information
Dear Colleagues,
Mitochondrial defects and mitochondrial decline have been implicated in a wide spectrum of metabolic disorders, age-related metabolic and degenerative diseases, aging, and cancer. For example, mitochondrial dysfunction in various tissues has been associated with the pathology of type 2 mellitus diabetes and metabolic syndrome, while a reduction in the oxidative capacity of mitochondria and an increase in the generation of reactive oxygen species (ROS) contribute to increased insulin resistance. Sirtuins are NAD+-dependent protein deacetylases that are involved in the regulation of metabolic diseases, stress responses, and aging. Three sirtuins are located in mitochondria, including SIRT3, 4, and 5. SIRT3 deacetylates and regulates the enzymatic activity of many metabolic enzymes in mitochondria, whereas SIRT5 removes two novel post-translational modifications, namely lysine malonylation and succinylation. Among the three mitochondrial sirtuins, Sirt3 is of particular interest with regard to mitochondrial function and drug targeting because it is primarily localized in the mitochondria and is a major mitochondrial deacetylase. Sirt3 also regulates mitochondrial biogenesis via the deacetylation of PGC-1α and several mitochondrial substrates to control metabolic homeostasis. It is therefore crucial to enhance our understanding of how mitochondrial sirtuins affect systemic metabolism in order to identify targets that may facilitate the prevention and treatment of type 2 diabetes and metabolic disorders. This Special Issue will focus on mitochondrial sirtuins, especially Sirt3, a gene could be utilized as a drug target for type 2 diabetes and metabolic syndromes.
Dr. Linh Ho
Prof. Dr. Tibebe Woldemariam
Guest Editors
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Keywords
- mitochondrial sirtuins
- Sirt3
- Sirt5
- metabolic disorders
- type 2 diabetes
- drug targets
- insulin resistance
- reactive oxygen species (ROS)
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