Special Issue "Biofilm-Based Nosocomial Infections"
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: closed (30 September 2014) | Viewed by 129392
A printed edition of this Special Issue is available here.
Interests: microbiology; microbial biofilms; healthcare-associated infections; biomaterial-associated infections; role of toxins and other virulence factors in microbial pathogenesis
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Microbial biofilms have been implicated in a large number of acute and chronic infections, as well as in the failure of antibiotic treatment, particularly in hospitalized patients. In fact, the well-known persistence in the nosocomial environment of multidrug resistant microorganisms is believed to be highly promoted by the ability of the great majority of the involved bacterial and fungal species to adhere on living or abiotic surfaces, and to grow in sessile mode, to form single- or multi-species biofilms. In these communities, microbes grow encased in a hydrated matrix of extracellular polymeric substances produced by themselves and are well protected from the host immune response and the attack of antimicrobial molecules. Thus, the establishment of microbial biofilm communities on the mucosal and soft tissues of hospitalized patients, as well as on the surfaces of indwelling devices and medical instruments, is expected to have a great influence on the success of the antibiotic therapies against most of the bugs involved in nosocomial infections, being biofilm-growing bacteria and fungi much less susceptible to antibiotics.
The aim of this Special Issue will be to report the state-of-art developments in the field of biofilm-based nosocomial infections that can be acquired by patients in both general hospitals and long-term care settings. Particularly, the involvement of biofilms in medical device-related infections and other healthcare-associated infections, which have so far been underestimated and scarcely investigated, will be reviewed.
Prof. Dr. Gianfranco Donelli
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- bacterial biofilms
- fungal biofilms
- nosocomial Infections
- antibiotic resistance
- healthcare-associated infections
- multidrug resistant microorganisms
- medical devices
- medical instruments
- general hospitals
- long-term care settings