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Exploring Dangerous Connections between Klebsiella pneumoniae Biofilms and Healthcare-Associated Infections
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Pathogens 2014, 3(3), 743-758;

Antibiotic Resistance Related to Biofilm Formation in Klebsiella pneumoniae

Microbial Biofilm Laboratory, IRCCS Fondazione Santa Lucia, Rome 00179, Italy
Clinical Microbiology Laboratory, IRCCS Fondazione Santa Lucia, Rome 00179, Italy
Department of Biomedical Sciences and Public Health, Section of Microbiology, Polytechnic University of Marche, Ancona 60126, Italy
Author to whom correspondence should be addressed.
Received: 10 July 2014 / Revised: 2 September 2014 / Accepted: 3 September 2014 / Published: 5 September 2014
(This article belongs to the Special Issue Biofilm-Based Nosocomial Infections)
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The Gram-negative opportunistic pathogen, Klebsiella pneumoniae, is responsible for causing a spectrum of community-acquired and nosocomial infections and typically infects patients with indwelling medical devices, especially urinary catheters, on which this microorganism is able to grow as a biofilm. The increasingly frequent acquisition of antibiotic resistance by K. pneumoniae strains has given rise to a global spread of this multidrug-resistant pathogen, mostly at the hospital level. This scenario is exacerbated when it is noted that intrinsic resistance to antimicrobial agents dramatically increases when K. pneumoniae strains grow as a biofilm. This review will summarize the findings about the antibiotic resistance related to biofilm formation in K. pneumoniae. View Full-Text
Keywords: Klebsiella pneumonia; biofilm; antibiotic resistance Klebsiella pneumonia; biofilm; antibiotic resistance

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Vuotto, C.; Longo, F.; Balice, M.P.; Donelli, G.; Varaldo, P.E. Antibiotic Resistance Related to Biofilm Formation in Klebsiella pneumoniae. Pathogens 2014, 3, 743-758.

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