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Exploring Dangerous Connections between Klebsiella pneumoniae Biofilms and Healthcare-Associated Infections
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Antibiotic Resistance Related to Biofilm Formation in Klebsiella pneumoniae

1
Microbial Biofilm Laboratory, IRCCS Fondazione Santa Lucia, Rome 00179, Italy
2
Clinical Microbiology Laboratory, IRCCS Fondazione Santa Lucia, Rome 00179, Italy
3
Department of Biomedical Sciences and Public Health, Section of Microbiology, Polytechnic University of Marche, Ancona 60126, Italy
*
Author to whom correspondence should be addressed.
Pathogens 2014, 3(3), 743-758; https://doi.org/10.3390/pathogens3030743
Received: 10 July 2014 / Revised: 2 September 2014 / Accepted: 3 September 2014 / Published: 5 September 2014
(This article belongs to the Special Issue Biofilm-Based Nosocomial Infections)
The Gram-negative opportunistic pathogen, Klebsiella pneumoniae, is responsible for causing a spectrum of community-acquired and nosocomial infections and typically infects patients with indwelling medical devices, especially urinary catheters, on which this microorganism is able to grow as a biofilm. The increasingly frequent acquisition of antibiotic resistance by K. pneumoniae strains has given rise to a global spread of this multidrug-resistant pathogen, mostly at the hospital level. This scenario is exacerbated when it is noted that intrinsic resistance to antimicrobial agents dramatically increases when K. pneumoniae strains grow as a biofilm. This review will summarize the findings about the antibiotic resistance related to biofilm formation in K. pneumoniae. View Full-Text
Keywords: Klebsiella pneumonia; biofilm; antibiotic resistance Klebsiella pneumonia; biofilm; antibiotic resistance
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Vuotto, C.; Longo, F.; Balice, M.P.; Donelli, G.; Varaldo, P.E. Antibiotic Resistance Related to Biofilm Formation in Klebsiella pneumoniae. Pathogens 2014, 3, 743-758.

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