Next Article in Journal
Proteomic Differences between Listeria monocytogenes Isolates from Food and Clinical Environments
Next Article in Special Issue
Biofilms in Infections of the Eye
Previous Article in Journal
Comparison of Potato and Asian Citrus Psyllid Adult and Nymph Transcriptomes Identified Vector Transcripts with Potential Involvement in Circulative, Propagative Liberibacter Transmission
Previous Article in Special Issue
Evolution of Antimicrobial Peptides to Self-Assembled Peptides for Biomaterial Applications
Article Menu

Export Article

Open AccessArticle
Pathogens 2014, 3(4), 908-919;

Antimicrobial and Antibiofilm Activity of Chitosan on the Oral Pathogen Candida albicans

Universidade Católica Portuguesa/Porto, Rua Arquiteto Lobão Vital, Apartado 2511, 4202-401 Porto, Portugal
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 26 September 2014 / Revised: 3 December 2014 / Accepted: 4 December 2014 / Published: 11 December 2014
(This article belongs to the Special Issue Biofilm-Based Nosocomial Infections)
Full-Text   |   PDF [1065 KB, uploaded 11 December 2014]   |  


Oral candidiasis is particularly evident, not only in cancer patients receiving chemotherapy, but also in elderly people with xerostomy. In general, Candida is an opportunistic pathogen, causing infections in immunocompromised people and, in some cases, when the natural microbiota is altered. Chitosan, a natural derivative of chitin, is a polysaccharide that has been proven to possess a broad spectrum of antimicrobial activity that encompasses action against fungi, yeast and bacteria. While recent studies have revealed a significant antibiofilm activity upon several microorganisms, including C. albicans, little is known regarding the impact of chitosan upon the adhesive process or mature biofilms. With that in mind, the purpose of this work was to evaluate, in vitro, the capability of chitosan to inhibit C. albicans growth and biofilm formation. The results obtained showed that chitosan is capable of inhibiting C. albicans planktonic growth (HMW, 1 mg/mL; LMW, 3 mg/mL). Regarding biofilm growth, chitosan inhibited C. albicans adhesion (ca. 95%), biofilm formation (percentages above 90%) and reduced mature biofilms by ca. 65% and dual species biofilms (C. albicans and S. mutans) by ca. 70%. These results display the potential of this molecule to be used as an effective anti-Candida agent capable of acting upon C. albicans infections. View Full-Text
Keywords: candidiasis; Candida albicans; chitosan; biofilm; antibiofilm candidiasis; Candida albicans; chitosan; biofilm; antibiofilm

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Costa, E.; Silva, S.; Tavaria, F.; Pintado, M. Antimicrobial and Antibiofilm Activity of Chitosan on the Oral Pathogen Candida albicans. Pathogens 2014, 3, 908-919.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Pathogens EISSN 2076-0817 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top