Special Issue "Dietary Plant Origin Bio-Active Compounds, Intestinal Functionality and Microbiome"
Deadline for manuscript submissions: closed (1 September 2020).
Interests: dietary micronutrients; Fe and Zn deficiencies; anemia; Zn status biomarkers; bioactive compounds; prebiotics; microbiome; nutrigenomics; intestinal functionality and development; polyphenols; in vivo models of human nutrition
Special Issues and Collections in MDPI journals
Special Issue in Nutrients: Dietary Zn and Human Health
Special Issue in Nutrients: Dietary Trace Minerals
Special Issue in Nutrients: Alleviating Zinc Dietary Deficiency, and Monitoring Poor Physiological Zinc Status in Sensitive Populations
Special Issue in Nutrients: Dietary Polyphenols and Flavanoids, Mineral Bioavailability, Gut Functionality, Morphology and Microbiome
Plant-based diets contain a plethora of metabolites that may impact on health and disease prevention. Most are focused on the potential bioactivity and nutritional relevance of several classes of phytochemicals, such as polyphenols, flavonoids, carotenoids, phyto-oestrogens, and frucrooligo-saccharides. These compounds are found in fruit, vegetables, and herbs. Daily intakes of some of these compounds may exceed 100 mg. Moreover, intestinal bacterial activity may transform complex compounds such as anthocyanins, procyanidins, and isoflavones into simple phenolic metabolites. The colon is thus a rich source of potentially active phenolic acids that may impact both locally and systemically on gut health. Further, nondigestible fiber (prebiotics) are dietary substrates that selectively promote proliferation and/or activity of health-promoting bacterial populations in the colon. Prebiotics, such as inulin, raffinose, and stachyose, have a proven ability to promote the abundance of intestinal bacterial populations, which may provide additional health benefits to the host. Further, various pulse seed soluble (fiber) extracts are responsible for improving gastrointestinal motility, intestinal functionality and morphology, and mineral absorption. Studies indicated that the consumption of seed origin soluble extracts can upregulate the expression of BBM proteins that contribute for digestion and absorption of nutrients. The soluble extracts can positively affect intestinal health by increasing the mucus production, goblet cells number/diameter, villus surface area, and crypt depth. These functional and morphological effects appears to occur due to the increased motility of the digestive tract, leading to hyperplasia and/or hypertrophy of muscle cells. Plant origin soluble extracts may act, directly or indirectly, as a factor that increases mineral solubility and, therefore, dietary bioavailability. This occurs due to fiber fermentation and bacterial production of SCFA that reduces intestinal pH, inhibits the growth of potentially pathogenic bacterial population and increases the solubility and, therefore, absorption of minerals. The SCFA can increase the proliferation of epithelial cells, which, in return, increase the absorptive surface area, which contributes to the absorption of nutrients. Several phenolic acids and other phytochemicals affect the expression and activity of enzymes involved in the production of inflammatory mediators of pathways thought to be important in the development of gut disorders including colon cancer. However, it is still unclear as to which of these compounds are beneficial to gut health. Hence, the aim of the current Special Issue is to further explore the interactions between dietary plant origin bioactive compounds, their potential effects on the intestinal bacterial populations, and overall intestinal functionality and gut health.
Dr. Elad Tako
Manuscript Submission Information
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- Bioactive compounds
- Brush border membrane functionality
- Intestinal microbiome