Neuroglia at the Crossroads: Emerging Insights into Neurological Disease Mechanisms

Dear Colleagues,

Glial cells, once regarded as passive support cells in the nervous system, are now recognized as dynamic regulators of brain homeostasis, immunity, synaptic plasticity, and neurovascular integrity. Recent discoveries have highlighted their central role in the pathophysiology of a wide range of neurological diseases, from neurodevelopmental disorders and epilepsy to neurodegeneration, stroke, and neuroinflammation. This Special Issue, “Neuroglia at the Crossroads: Emerging Insights into Neurological Disease Mechanisms”,  aims to capture the rapidly evolving landscape of glial research and provide a curated collection of cutting-edge studies that explore how astrocytes, microglia, oligodendrocytes, and other glial subtypes contribute to disease onset, progression, and potential recovery.

We invite contributions that dissect glial signaling pathways, glia–neuron and glia–vascular interactions, and metabolic and immune functions of glia, as well as studies leveraging omics, imaging, and novel in vitro/in vivo models. Of particular interest are investigations revealing context-dependent glial plasticity, cell-type-specific vulnerabilities, or the therapeutic potential of glia-targeted interventions. Both original research and in-depth reviews will be considered.

By bringing together interdisciplinary insights, “Neuroglia at the Crossroads” will serve as a vital reference point for researchers and clinicians alike—illuminating how decoding glial biology may hold the key to solving some of the most challenging problems in neuroscience today.

Dr. Ruoli Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Neuroglia is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.