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Nanomaterials
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Nanocarriers and Drug Delivery
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Nanocarriers and Drug Delivery

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (1 October 2022) | Viewed by 13698

Special Issue Editor

Prof. Dr. Suming Li

E-Mail Website
Guest Editor
Institut Européen des Membranes, UMR CNRS 5635, Université de Montpellier, 34095 Montpellier, France
Interests: biobased; biodegradable; biocompatible; biopolymer; colloidal system; hydrogels; micelles; nanoparticles; nanocomposite; self-assembly; block copolymer; drug delivery; tissue engineering

Special Issue Information

Dear Colleagues,

Nanotechnology is helping to considerably improve, even revolutionize, many technology and industry sectors, including medicine, pharmacology, information technology, energy, food safety, and environmental science. With the advances in nanotechnology, nano-carriers have been extensively investigated for biomedical applications in medical imaging, disease diagnosis, and in particular in drug delivery as they enable to improve the drug bioavailability, and to reduce the dosing frequency and side effects.

The aim of this Special Issue is to aim to provide an overview of the state of the art in this domain, highlighting the continuing efforts to design, synthesize, and apply nanomaterials as nanocarriers in drug delivery, especially in cancer therapy. We welcome contributions regarding the synthesis and characterization of nanomaterials, formulation of nanocarriers (nanoparticles, micelles, nanogels, polymersomes, etc.), in vitro and in vivo drug release, and in-depth understanding of the mechanisms governing drug loading and drug release of nanocarriers.

Prof. Dr. Suming Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanocarrier
  • nanoparticle
  • micelle
  • nanogel
  • polymersome
  • drug release
  • anti-tumor drug

Published Papers (5 papers)

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Research

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26 pages, 5018 KiB  
Article
Functionalized Mesoporous Silica as Doxorubicin Carriers and Cytotoxicity Boosters
by Carmen Racles, Mirela-Fernanda Zaltariov, Dragos Peptanariu, Tudor Vasiliu and Maria Cazacu
Nanomaterials 2022, 12(11), 1823; https://doi.org/10.3390/nano12111823 - 26 May 2022
Cited by 7 | Viewed by 1636
Abstract
Mesoporous silica nanoparticles (MSNs) bearing methyl, thiol or glucose groups were synthesized, and their encapsulation and release behaviors for the anticancer drug Doxorubicin (Dox) were investigated in comparison with nonporous homologous materials. The chemical modification of thiol-functional silica with a double bond glucoside [...] Read more.
Mesoporous silica nanoparticles (MSNs) bearing methyl, thiol or glucose groups were synthesized, and their encapsulation and release behaviors for the anticancer drug Doxorubicin (Dox) were investigated in comparison with nonporous homologous materials. The chemical modification of thiol-functional silica with a double bond glucoside was completed for the first time, by green thiol-ene photoaddition. The MSNs were characterized in terms of structure (FT-IR, Raman), morphology (TEM), porosity (nitrogen sorption–desorption) and Zeta potential measurements. The physical interactions responsible for the Dox encapsulation were investigated by analytic methods and MD simulations, and were correlated with the high loading efficiency of MSNs with thiol and glucose groups. High release at pH 5 was observed in most cases, with thiol-MSN exhibiting 98.25% cumulative release in sustained profile. At pH 7.4, the glucose-MSN showed 75.4% cumulative release, while the methyl-MSN exhibited a sustained release trend. The in vitro cytotoxicity was evaluated on NDHF, MeWo and HeLa cell lines by CellTiter-Glo assay, revealing strong cytotoxic effects in all of the loaded silica at low equivalent Dox concentration and selectivity for cancer cells. Atypical applications of each MSN as intravaginal, topical or oral Dox administration route could be proposed. Full article
(This article belongs to the Special Issue Nanocarriers and Drug Delivery)
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18 pages, 3573 KiB  
Article
Co-Loading of Temozolomide and Curcumin into a Calix[4]arene-Based Nanocontainer for Potential Combined Chemotherapy: Binding Features, Enhanced Drug Solubility and Stability in Aqueous Medium
by Rossella Migliore, Nicola D’Antona, Carmelo Sgarlata and Grazia M. L. Consoli
Nanomaterials 2021, 11(11), 2930; https://doi.org/10.3390/nano11112930 - 2 Nov 2021
Cited by 15 | Viewed by 2174
Abstract
The co-delivery of anticancer drugs into tumor cells by a nanocarrier may provide a new paradigm in chemotherapy. Temozolomide and curcumin are anticancer drugs with a synergistic effect in the treatment of multiform glioblastoma. In this study, the entrapment and co-entrapment of temozolomide [...] Read more.
The co-delivery of anticancer drugs into tumor cells by a nanocarrier may provide a new paradigm in chemotherapy. Temozolomide and curcumin are anticancer drugs with a synergistic effect in the treatment of multiform glioblastoma. In this study, the entrapment and co-entrapment of temozolomide and curcumin in a p-sulfonato-calix[4]arene nanoparticle was investigated by NMR spectroscopy, UV-vis spectrophotometry, isothermal titration calorimetry, and dynamic light scattering. Critical micellar concentration, nanoparticle size, zeta potential, drug loading percentage, and thermodynamic parameters were all consistent with a drug delivery system. Our data showed that temozolomide is hosted in the cavity of the calix[4]arene building blocks while curcumin is entrapped within the nanoparticle. Isothermal titration calorimetry evidenced that drug complexation and entrapment are entropy driven processes. The loading in the calixarene-based nanocontainer enhanced the solubility and half-life of both drugs, whose medicinal efficacy is affected by low solubility and rapid degradation. The calixarene-based nanocontainer appears to be a promising new candidate for nanocarrier-based drug combination therapy for glioblastoma. Full article
(This article belongs to the Special Issue Nanocarriers and Drug Delivery)
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22 pages, 6300 KiB  
Article
Nanogold-Carried Graphene Oxide: Anti-Inflammation and Increased Differentiation Capacity of Mesenchymal Stem Cells
by Huey-Shan Hung, Mei-Lang Kung, Fang-Chung Chen, Yi-Chun Ke, Chiung-Chyi Shen, Yi-Chin Yang, Chang-Ming Tang, Chun-An Yeh, Hsien-Hsu Hsieh and Shan-hui Hsu
Nanomaterials 2021, 11(8), 2046; https://doi.org/10.3390/nano11082046 - 11 Aug 2021
Cited by 16 | Viewed by 3434
Abstract
Graphene-based nanocomposites such as graphene oxide (GO) and nanoparticle-decorated graphene with demonstrated excellent physicochemical properties have worthwhile applications in biomedicine and bioengineering such as tissue engineering. In this study, we fabricated gold nanoparticle-decorated GO (GO-Au) nanocomposites and characterized their physicochemical properties using UV-Vis [...] Read more.
Graphene-based nanocomposites such as graphene oxide (GO) and nanoparticle-decorated graphene with demonstrated excellent physicochemical properties have worthwhile applications in biomedicine and bioengineering such as tissue engineering. In this study, we fabricated gold nanoparticle-decorated GO (GO-Au) nanocomposites and characterized their physicochemical properties using UV-Vis absorption spectra, FTIR spectra, contact angle analyses, and free radical scavenging potential. Moreover, we investigated the potent applications of GO-Au nanocomposites on directing mesenchymal stem cells (MSCs) for tissue regeneration. We compared the efficacy of as-prepared GO-derived nanocomposites including GO, GO-Au, and GO-Au (×2) on the biocompatibility of MSCs, immune cell identification, anti-inflammatory effects, differentiation capacity, as well as animal immune compatibility. Our results showed that Au-deposited GO nanocomposites, especially GO-Au (×2), significantly exhibited increased cell viability of MSCs, had good anti-oxidative ability, sponged the immune response toward monocyte-macrophage transition, as well as inhibited the activity of platelets. Moreover, we also validated the superior efficacy of Au-deposited GO nanocomposites on the enhancement of cell motility and various MSCs-derived cell types of differentiation including neuron cells, adipocytes, osteocytes, and endothelial cells. Additionally, the lower induction of fibrotic formation, reduced M1 macrophage polarization, and higher induction of M2 macrophage, as well as promotion of the endothelialization, were also found in the Au-deposited GO nanocomposites implanted animal model. These results suggest that the Au-deposited GO nanocomposites have excellent immune compatibility and anti-inflammatory effects in vivo and in vitro. Altogether, our findings indicate that Au-decorated GO nanocomposites, especially GO-Au (×2), can be a potent nanocarrier for tissue engineering and an effective clinical strategy for anti-inflammation. Full article
(This article belongs to the Special Issue Nanocarriers and Drug Delivery)
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8 pages, 1005 KiB  
Article
Colloidal Assemblies Composed of Polymeric Micellar/Emulsified Systems Integrate Cancer Therapy Combining a Tumor-Associated Antigen Vaccine and Chemotherapeutic Regimens
by Chiung-Yi Huang, Shu-Yu Lin, Tsu-An Hsu, Hsing-Pang Hsieh and Ming-Hsi Huang
Nanomaterials 2021, 11(7), 1844; https://doi.org/10.3390/nano11071844 - 16 Jul 2021
Cited by 2 | Viewed by 1964
Abstract
Integrative medicine comprising a tumor-associated antigen vaccine and chemotherapeutic regimens has provided new insights into cancer therapy. In this study, the AB-type diblock copolymers poly(ethylene glycol)–polylactide (PEG–PLA) were subjected to the dispersion of poorly water-soluble molecules in aqueous solutions. The physicochemical behavior of [...] Read more.
Integrative medicine comprising a tumor-associated antigen vaccine and chemotherapeutic regimens has provided new insights into cancer therapy. In this study, the AB-type diblock copolymers poly(ethylene glycol)–polylactide (PEG–PLA) were subjected to the dispersion of poorly water-soluble molecules in aqueous solutions. The physicochemical behavior of the chemotherapeutic agent DBPR114 in the PEG–PLA-polymeric aqueous solution was investigated by dynamic light scattering (DLS) technology. In vitro cell culture indicated that replacing the organic solvent DMSO with PEG–PLA polymeric micelles could maintain the anti-proliferative effect of DBPR114 on leukemia cell lines. A murine tumor-associated antigen vaccine model was established in tumor-bearing mice to determine the effectiveness of these formulas in inducing tumor regression. The results demonstrated that the therapeutic treatments effectively reinforced each other via co-delivery of antitumor drug/antigen agents to synergistically integrate the efficacy of cancer therapy. Our findings support the potential use of polymeric micellar systems for aqueous solubilization and expansion of antitumor activity intrinsic to DBPR114 and tumor-associated antigen therapy. Full article
(This article belongs to the Special Issue Nanocarriers and Drug Delivery)
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Review

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18 pages, 1630 KiB  
Review
Bioactive Based Nanocarriers for the Treatment of Viral Infections and SARS-CoV-2
by Ravi Goyal, Rajni Bala, Rakesh K. Sindhu, Mehrukh Zehravi, Reecha Madaan, Sarker Ramproshad, Banani Mondal, Abhijit Dey, Md. Habibur Rahman and Simona Cavalu
Nanomaterials 2022, 12(9), 1530; https://doi.org/10.3390/nano12091530 - 1 May 2022
Cited by 8 | Viewed by 3192
Abstract
Since ancient times, plants have been used for their medicinal properties. They provide us with many phytomolecules, which serve a synergistic function for human well-being. Along with anti-microbial, plants also possess anti-viral activities. In Western nations, about 50% of medicines were extracted from [...] Read more.
Since ancient times, plants have been used for their medicinal properties. They provide us with many phytomolecules, which serve a synergistic function for human well-being. Along with anti-microbial, plants also possess anti-viral activities. In Western nations, about 50% of medicines were extracted from plants or their constituents. The spread and pandemic of viral diseases are becoming a major threat to public health and a burden on the financial prosperity of communities worldwide. In recent years, SARS-CoV-2 has made a dramatic lifestyle change. This has promoted scientists not to use synthetic anti-virals, such as protease inhibitors, nucleic acid analogs, and other anti-virals, but to study less toxic anti-viral phytomolecules. An emerging approach includes searching for eco-friendly therapeutic molecules to develop phytopharmaceuticals. This article briefly discusses numerous bioactive molecules that possess anti-viral properties, their mode of action, and possible applications in treating viral diseases, with a special focus on coronavirus and various nano-formulations used as a carrier for the delivery of phytoconstituents for improved bioavailability. Full article
(This article belongs to the Special Issue Nanocarriers and Drug Delivery)
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