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Advanced Nanomaterials for Tissue Engineering Applications

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A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (15 April 2022) | Viewed by 9945

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Special Issue Editor

Prof. Dr. Andreas Arkudas

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Guest Editor

Department of Plastic and Hand Surgery, Laboratory for Tissue Engineering and Regenerative Medicine, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany
Interests: microsurgery; flap surgery; hand surgery; reconstructive surgery; tissue engineering; biofabrication
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Special Issue Information

Dear Colleagues,

The term “tissue engineering” was first mentioned in the 80s and since then researchers have tried to mimic nature to engineer tissues to replace organs or isolated biological structures. Most of these studies rely on a biomaterial as a scaffold, specific cells, and growth-stimulating signals. In the last few decades, various publications on the great achievement concerning different tissues have been published. Nevertheless, most of these publications are in vitro and have not yet been adopted in the clinical scenario. One major challenge in bringing the in vitro results into clinical dimensions is the lack of vascularization of tissue-engineered constructs.

This Special Issue of Nanomaterials focusses on the following topics:

Biomaterials for bone/muscle/skin/vessel tissue engineering
Angiogenesis of tissue-engineered constructs
Interaction of cells and biomaterials
Biomaterials for organ tissue engineering
Biomaterials with incorporated growth-stimulating signals
In vivo tissue engineering models for bridging bench to bedside

Please submit your article with the latest achievements in these fields to the journal.

Prof. Dr. Andreas Arkudas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Tissue engineering
Biomaterials
Bone
Muscle
Skin
Vessel
Growth-stimulating signals
Angiogenesis
Cells

Published Papers (3 papers)

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Research

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15 pages, 4159 KiB

Open AccessEditor’s ChoiceArticle

Examining the Transmission of Visible Light through Electrospun Nanofibrous PCL Scaffolds for Corneal Tissue Engineering

by Marcus Himmler, Dirk W. Schubert and Thomas A. Fuchsluger

Nanomaterials 2021, 11(12), 3191; https://doi.org/10.3390/nano11123191 - 25 Nov 2021

Cited by 9 | Viewed by 2108

Abstract

The transparency of nanofibrous scaffolds is of highest interest for potential applications like corneal wound dressings in corneal tissue engineering. In this study, we provide a detailed analysis of light transmission through electrospun polycaprolactone (PCL) scaffolds. PCL scaffolds were produced via electrospinning, with fiber diameters in the range from (35 ± 13) nm to (167 ± 35) nm. Light transmission measurements were conducted using UV–vis spectroscopy in the range of visible light and analyzed with respect to the influence of scaffold thickness, fiber diameter, and surrounding medium. Contour plots were compiled for a straightforward access to light transmission values for arbitrary scaffold thicknesses. Depending on the fiber diameter, transmission values between 15% and 75% were observed for scaffold thicknesses of 10 µm. With a decreasing fiber diameter, light transmission could be improved, as well as with matching refractive indices of fiber material and medium. For corneal tissue engineering, scaffolds should be designed as thin as possible and fabricated from polymers with a matching refractive index to that of the human cornea. Concerning fiber diameter, smaller fiber diameters should be favored for maximizing graft transparency. Finally, a novel, semi-empirical formulation of light transmission through nanofibrous scaffolds is presented. Full article

(This article belongs to the Special Issue Advanced Nanomaterials for Tissue Engineering Applications)

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12 pages, 4675 KiB

Open AccessArticle

Mechanical, Electrical, and Biological Properties of Mechanochemically Processed Hydroxyapatite Ceramics

by Sujata Swain, Rakesh Bhaskar, Mukesh Kumar Gupta, Sonia Sharma, Sudip Dasgupta, Anuj Kumar and Pawan Kumar

Nanomaterials 2021, 11(9), 2216; https://doi.org/10.3390/nano11092216 - 28 Aug 2021

Cited by 19 | Viewed by 2033

Abstract

The effect of the sintering temperature on densification and the resultant mechanical, electrical, and biological properties of mechanochemically processed hydroxyapatite (HAp) samples was investigated. HAp samples were sintered at 1200, 1250, and 1300 °C for 4 h, respectively. HAp samples sintered at 1250 °C showed better mechanical properties, which was attributed to their smaller grain size compared to HAp samples at higher sintering temperatures. The nearly identical value of the dielectric constant (ε_r) and better cell proliferation was exhibited by HAp samples sintered at 1250 and 1300 °C, respectively. At ~210 °C, in all the samples sintered at different temperatures, a dielectric anomaly was obtained, which was attributed to the phase transition temperature of the HAp system. Dielectric properties near the phase transition temperature showed a dielectric relaxation-type of behavior, which was attributed to the re-orientational motion of OH⁻ ions in the HAp system. Higher cell proliferation and viability were exhibited by the HAp1300 samples, whereas comparatively equivalent cell growth and higher mechanical strength were observed in the HAp1250 samples. Full article

(This article belongs to the Special Issue Advanced Nanomaterials for Tissue Engineering Applications)

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Review

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72 pages, 3944 KiB

Open AccessEditor’s ChoiceReview

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

by Ralf P. Friedrich, Iwona Cicha and Christoph Alexiou

Nanomaterials 2021, 11(9), 2337; https://doi.org/10.3390/nano11092337 - 8 Sep 2021

Cited by 53 | Viewed by 7463

Abstract

In recent years, many promising nanotechnological approaches to biomedical research have been developed in order to increase implementation of regenerative medicine and tissue engineering in clinical practice. In the meantime, the use of nanomaterials for the regeneration of diseased or injured tissues is considered advantageous in most areas of medicine. In particular, for the treatment of cardiovascular, osteochondral and neurological defects, but also for the recovery of functions of other organs such as kidney, liver, pancreas, bladder, urethra and for wound healing, nanomaterials are increasingly being developed that serve as scaffolds, mimic the extracellular matrix and promote adhesion or differentiation of cells. This review focuses on the latest developments in regenerative medicine, in which iron oxide nanoparticles (IONPs) play a crucial role for tissue engineering and cell therapy. IONPs are not only enabling the use of non-invasive observation methods to monitor the therapy, but can also accelerate and enhance regeneration, either thanks to their inherent magnetic properties or by functionalization with bioactive or therapeutic compounds, such as drugs, enzymes and growth factors. In addition, the presence of magnetic fields can direct IONP-labeled cells specifically to the site of action or induce cell differentiation into a specific cell type through mechanotransduction. Full article

(This article belongs to the Special Issue Advanced Nanomaterials for Tissue Engineering Applications)

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