Special Issue "Synthesis and Application of Antimicrobial Nanomaterials"

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 30 September 2020.

Special Issue Editor

Dr. László Kőrösi
Website
Guest Editor
University of Pécs, Research Institute for Viticulture and Oenology, 7634 Pécs, Hungary
Interests: materials science; metal oxide nanoparticles; titanium dioxide; sol–gel synthesis; hydrothermal synthesis; photocatalysis; antibacterial nanomaterials; plant polyphenols

Special Issue Information

Dear Colleagues,

The rapid adaptation of microorganisms to conventional antibiotics requires the continuous design and production of new antimicrobial agents. This human fight against bacterial pathogens frequently leads to the selection and emergence of multidrug-resistant (MDR) strains in the community and hospital environments. Since the proportion of MDR bacterial infections is alarmingly increasing year by year, novel approaches are required to effectively handle this global healthcare problem. The effective control of pathogens is of great importance not only in the health care system but also in food safety. Several dangerous microorganisms, including some MDR strains, can contaminate the food chain and evoke foodborne diseases. The number of these cases is estimated to be 600 million per year worldwide. Thus, antimicrobial surfaces play key role for transporting or packaging foods. Besides killing the human pathogens, the inactivation of phytopathogenic microbes is also a big challenge. At present, a large amount and a wide range of chemicals are used for plant protection. Resistant phytopathogenic microbes and inefficient protection against them cause enormous economic damage.

Consequently, it is necessary to develop advanced and effective materials against both human and plant pathogens. For this purpose, nanomaterials with high antimicrobial activity may provide an alternative solution. In recent years, diverse antimicrobial nanomaterials (AMI NMs) have been explored, and they have received a great deal of attention because of their high effectiveness. One of the largest groups of AMI NMs is comprised of those able to produce reactive oxygen species (ROS). ROS produced by photoinduced processes (photocatalysis) or indirectly even without the application of light (e.g., Ag, MgO NMs) are effective tools in the inactivation of pathogens. The investigation and exploitation of these unique nanomaterials have been constantly and dynamically growing in the fields of both medicine and agriculture.

In this Special Issue, we look forward to receiving the submission of high-quality and original research works which focus on advanced ROS-based antimicrobial nanomaterials against both human and plant pathogens.

The scope includes, but is not limited to:

  • Chemical, physical, and “green” synthesis of AMI NMs;
  • Reactive oxygen species generation by AMI NMs;
  • Photocatalytically active metal-oxide-based AMI NMs;
  • Noble-metal-based AMI NMs;
  • Antimicrobial nanopowders, thin films, and coatings;
  • Nanocomposites and surface-functionalized AMI NMs;
  • Application of AMI NMs against human pathogens or phytopathogenic microbes;
  • Efficacy comparisons of potential AMI NMs.
Dr. László Kőrösi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multidrug-resistant bacteria
  • foodborne pathogens
  • phytopathogenic microbes
  • antimicrobial nanopowders and coatings
  • nanocomposites
  • green synthesis
  • reactive oxygen species
  • photocatalytic disinfection
  • functionalized photocatalysts
  • noble metals.

Published Papers (4 papers)

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Research

Open AccessArticle
Synergetic Effect of 2-Methacryloyloxyethyl Phosphorylcholine and Mesoporous Bioactive Glass Nanoparticles on Antibacterial and Anti-Demineralisation Properties in Orthodontic Bonding Agents
Nanomaterials 2020, 10(7), 1282; https://doi.org/10.3390/nano10071282 - 30 Jun 2020
Abstract
2-methacryloyloxyethyl phosphorylcholine (MPC) is known to have antibacterial and protein-repellent effects, whereas mesoporous bioactive glass nanoparticles (MBN) are known to have remineralisation effects. We evaluated the antibacterial and remineralisation effects of mixing MPC and MBN at various ratios with orthodontic bonding agents. MPC [...] Read more.
2-methacryloyloxyethyl phosphorylcholine (MPC) is known to have antibacterial and protein-repellent effects, whereas mesoporous bioactive glass nanoparticles (MBN) are known to have remineralisation effects. We evaluated the antibacterial and remineralisation effects of mixing MPC and MBN at various ratios with orthodontic bonding agents. MPC and MBN were mixed in the following weight percentages in CharmFil-Flow (CF): CF, 3% MPC, 5% MPC, 3% MPC + 3% MBN, and 3% MPC + 5% MBN. As the content of MPC and MBN increased, the mechanical properties of the resin decreased. At 5% MPC, the mechanical properties decreased significantly with respect to CF (shear bond strength), gelation of MPC occurred, and no significant difference was observed in terms of protein adsorption compared to the control group. Composition 3% MPC + 5% MBN exhibited the lowest protein adsorption because the proportion of hydrophobic resin composite decreased; CF (91.8 ± 4.8 μg/mL), 3% MPC (73.9 ± 2.6 μg/mL), 3% MPC + 3% MBN (69.4 ± 3.6 μg/mL), and 3% MPC + 5% MBN (55.9 ± 1.6 μg/mL). In experiments against S. mutans and E. coli, addition of MPC and MBN resulted in significant antibacterial effects. In another experiment, the anti-demineralisation effect was improved when MPC was added, and when MBN was additionally added, it resulted in a synergetic effect. When MPC and MBN were added at an appropriate ratio to the orthodontic bonding agents, the protein-repellent, antibacterial, and anti-demineralisation effects were improved. This combination could thus be an alternative way of treating white spot lesions. Full article
(This article belongs to the Special Issue Synthesis and Application of Antimicrobial Nanomaterials)
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Open AccessArticle
Enhancement of Antibacterial Performance of Silver Nanowire Transparent Film by Post-Heat Treatment
Nanomaterials 2020, 10(5), 938; https://doi.org/10.3390/nano10050938 - 13 May 2020
Abstract
Silver nanomaterials (AgNMs) have been applied as antibacterial agents to combat bacterial infections that can cause disease and death. The antibacterial activity of AgNMs can be improved by increasing the specific surface area, so significant efforts have been devoted to developing various bottom-up [...] Read more.
Silver nanomaterials (AgNMs) have been applied as antibacterial agents to combat bacterial infections that can cause disease and death. The antibacterial activity of AgNMs can be improved by increasing the specific surface area, so significant efforts have been devoted to developing various bottom-up synthesis methods to control the size and shape of the particles. Herein, we report on a facile heat-treatment method that can improve the antibacterial activity of transparent silver nanowire (AgNW) films in a size-controllable, top-down manner. AgNW films were fabricated via spin-coating and were then heated at different temperatures (230 and 280 °C) for 30 min. The morphology and the degree of oxidation of the as-fabricated AgNW film were remarkably sensitive to the heat-treatment temperature, while the transparency was insensitive. As the heat-treatment temperature increased, the AgNWs spontaneously broke into more discrete wires and droplets, and oxidation proceeded faster. The increase in the heat-treatment temperature further increased the antibacterial activity of the AgNW film, and the heat treatment at 280 °C improved the antibacterial activity from 31.7% to 94.7% for Staphylococcus aureus, and from 57.0% to 98.7% for Escherichia coli. Following commonly accepted antibacterial mechanisms of AgNMs, we present a correlation between the antibacterial activity and surface observations of the AgNW film. Full article
(This article belongs to the Special Issue Synthesis and Application of Antimicrobial Nanomaterials)
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Open AccessArticle
Electrospun Active Biopapers of Food Waste Derived Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with Short-Term and Long-Term Antimicrobial Performance
Nanomaterials 2020, 10(3), 506; https://doi.org/10.3390/nano10030506 - 11 Mar 2020
Cited by 1
Abstract
This research reports about the development by electrospinning of fiber-based films made of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) derived from fermented fruit waste, so-called bio-papers, with enhanced antimicrobial performance. To this end, different combinations of oregano essential oil (OEO) and zinc oxide nanoparticles (ZnONPs) [...] Read more.
This research reports about the development by electrospinning of fiber-based films made of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) derived from fermented fruit waste, so-called bio-papers, with enhanced antimicrobial performance. To this end, different combinations of oregano essential oil (OEO) and zinc oxide nanoparticles (ZnONPs) were added to PHBV solutions and electrospun into mats that were, thereafter, converted into homogeneous and continuous films of ~130 μm. The morphology, optical, thermal, mechanical properties, crystallinity, and migration into food simulants of the resultant PHBV-based bio-papers were evaluated and their antimicrobial properties were assessed against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) in both open and closed systems. It was observed that the antimicrobial activity decreased after 15 days due to the release of the volatile compounds, whereas the bio-papers filled with ZnONPs showed high antimicrobial activity for up to 48 days. The electrospun PHBV biopapers containing 2.5 wt% OEO + 2.25 wt% ZnONPs successfully provided the most optimal activity for short and long periods against both bacteria. Full article
(This article belongs to the Special Issue Synthesis and Application of Antimicrobial Nanomaterials)
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Open AccessArticle
Silver Nanoparticles-Composing Alginate/Gelatine Hydrogel Improves Wound Healing In Vivo
Nanomaterials 2020, 10(2), 390; https://doi.org/10.3390/nano10020390 - 23 Feb 2020
Cited by 5
Abstract
Polymer hydrogels have been suggested as dressing materials for the treatment of cutaneous wounds and tissue revitalization. In this work, we report the development of a hydrogel composed of natural polymers (sodium alginate and gelatin) and silver nanoparticles (AgNPs) with recognized antimicrobial activity [...] Read more.
Polymer hydrogels have been suggested as dressing materials for the treatment of cutaneous wounds and tissue revitalization. In this work, we report the development of a hydrogel composed of natural polymers (sodium alginate and gelatin) and silver nanoparticles (AgNPs) with recognized antimicrobial activity for healing cutaneous lesions. For the development of the hydrogel, different ratios of sodium alginate and gelatin have been tested, while different concentrations of AgNO3 precursor (1.0, 2.0, and 4.0 mM) were assayed for the production of AgNPs. The obtained AgNPs exhibited a characteristic peak between 430–450 nm in the ultraviolet-visible (UV–Vis) spectrum suggesting a spheroidal form, which was confirmed by Transmission Electron Microscopy (TEM). Fourier Transform Infra-red (FT–IR) analysis suggested the formation of strong intermolecular interactions as hydrogen bonds and electrostatic attractions between polymers, showing bands at 2920, 2852, 1500, and 1640 cm−1. Significant bactericidal activity was observed for the hydrogel, with a Minimum Inhibitory Concentration (MIC) of 0.50 µg/mL against Pseudomonas aeruginosa and 53.0 µg/mL against Staphylococcus aureus. AgNPs were shown to be non-cytotoxic against fibroblast cells. The in vivo studies in female Wister rats confirmed the capacity of the AgNP-loaded hydrogels to reduce the wound size compared to uncoated injuries promoting histological changes in the healing tissue over the time course of wound healing, as in earlier development and maturation of granulation tissue. The developed hydrogel with AgNPs has healing potential for clinical applications. Full article
(This article belongs to the Special Issue Synthesis and Application of Antimicrobial Nanomaterials)
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