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Nanomaterials
Special Issues
Cytotoxicity Evaluation and Antibacterial Activity of Nanoscale Materials
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Cytotoxicity Evaluation and Antibacterial Activity of Nanoscale Materials

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (20 November 2024) | Viewed by 1272

Special Issue Editors

Prof. Dr. Luc Ferrari

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Guest Editor
Institut Jean Lamour, UMR 7198 CNRS-Université de Lorraine, Nancy, France
Interests: toxicology; nanotoxicology; alternative models; risk assessment
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Raphaël E. Duval

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Guest Editor
Dean, Faculty of Pharmacy, Université de Lorraine, CNRS, L2CM, 54000 Nancy, France
Interests: research of new anti-infectives; development of new strategies to fight antimicrobial resistance
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

For several years, nanoparticles and nanomaterials have been attracting growing interest across many fields, ranging from fundamental research to applications in industry, such as in catalysis, imaging, energy, and electronics, as well as in the environmental and pharmaceutical and biomedical fields. With the properties of nanoparticles and nanomaterials being intimately linked to their shape and size, they often differ significantly from those of larger particles, including for particles produced from the same basic element. Thus, in some cases, their properties can be “beneficial”, while, in others, there are certain effects that can be considered “toxic”. The question is whether these toxic effects concern humans or other species, such as microorganisms.

The objective of this Special Issue is to highlight recent advances in the research on nanoparticles and nanomaterials related to the evaluation of the cytotoxicity of nanoscale materials, as well as their antimicrobial properties (antibacterial, antifungal, etc.). This Special Issue may include original research articles and reviews on the assessment of cytotoxicity and antimicrobial properties of materials, which is a topic of interest, to ensure that the best choices are made regarding tests and approaches for assessing these properties and the mechanisms involved.

Prof. Dr. Luc Ferrari
Prof. Dr. Raphaël E. Duval
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterial
  • nanoparticles
  • toxicity
  • test
  • antibacterial activity
  • in vitro

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Published Papers (1 paper)

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22 pages, 4610 KiB  
Article
Curcumin-Functionalized Electrospun Nanofibrous Membranes with Antimicrobial Activity for Wound Healing
by Neraida Petrai, Konstantinos Loukelis and Maria Chatzinikolaidou
Nanomaterials 2025, 15(5), 388; https://doi.org/10.3390/nano15050388 - 3 Mar 2025
Viewed by 913
Abstract
Chronic or improperly healed wounds, either as a result of extended trauma or prolonged inflammatory response, affect a significant percentage of the world population. Hence, there is a growing interest in the development of biomimetic scaffolds that expedite wound closure at the early [...] Read more.
Chronic or improperly healed wounds, either as a result of extended trauma or prolonged inflammatory response, affect a significant percentage of the world population. Hence, there is a growing interest in the development of biomimetic scaffolds that expedite wound closure at the early stages. Curcumin (Cur) is a plant-derived polyphenol with antimicrobial activity, and it accelerates the wound contraction rate. Recently, electrospraying has emerged for the precise deposition of bioactive molecules into scaffolds to improve therapeutic outcomes. In this study, we produced membranes for wound healing and endowed them with antibacterial properties to promote the healing of impaired wounds. Unlike previous studies that incorporated curcumin directly into electrospun fibers, we employed electrospraying to coat curcumin onto PVA/KC membranes. This approach improves the curcumin bioavailability and release kinetics, ensuring sustained therapeutic action. Toward this end, we fabricated four types of membranes, poly(vinyl alcohol) PVA and PVA/kappa carrageenan (KC), using electrospinning, and PVA/KC/Cur5 and PVA/KC/Cur20, in which the PVA/KC membranes were coated with two different concentrations of Cur by electrospraying. All membranes showed low cytotoxicity, good cell adhesion, the capability of enabling cells to produce collagen, and an adequate degradation rate for wound-healing applications. Antibacterial evaluation showed that both Cur-loaded membranes increased the antibacterial efficacy against both Escherichia coli and Staphylococcus aureus compared with PVA and PVA/KC membranes. These findings highlight the potential of electrosprayed curcumin as an effective strategy for bioactive wound dressings. Full article
(This article belongs to the Special Issue Cytotoxicity Evaluation and Antibacterial Activity of Nanoscale Materials)
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