Synthesis of Functional Nanoparticles for Biomedical Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 12 September 2025 | Viewed by 706

Special Issue Editors


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Guest Editor
Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Science, Niezapominajek 8, 30-239 Cracow, Poland
Interests: protein adsorption; mechanisms of protein adsorption; immune assays; polystyrene microparticles; metal nanoparticles; fluorescent metal nanoclusters

E-Mail Website
Guest Editor
Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Science, Niezapominajek 8, 30-239 Cracow, Poland
Interests: protein adsorption; mechanisms of protein adsorption; stability of biocolloidal suspensions; adsorption of biocolloidal particles; fluorescent metal nanoclusters; nanoparticles; streaming potential; biosensors
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Special Issue Information

Dear Colleagues,

The synthesis of novel functional nanoparticles is one of the most dynamic and sought-after areas in modern chemical science. Researchers are developing methods to synthesize various types of nanoparticles to create materials that possess unique physical and chemical properties while enhancing their practical functionality. Functional nanoparticles hold great promise, particularly in biomedicine and pharmaceuticals, where the distinctive properties of materials at the nanoscale can be effectively utilized.

These nanoparticles are notable for their high multifunctionality, which is due to their unique physicochemical characteristics, such as controlled morphology and versatile surface modification capabilities. A wide range of materials—including polymers, metal oxides, silica, noble metals, and carbon—can be used to fabricate nanoparticles. These structures can be engineered specifically to deliver bioactive substances, such as proteins, nucleic acids, or small molecules, thereby enabling a variety of biomedical applications.

This Special Issue focuses on cutting-edge research in the synthesis of novel nanoparticles and the functionalization of existing ones with bioactive agents to facilitate their use in biomedical contexts. It also welcomes studies that explore innovative techniques for synthesizing and characterizing functional nanoparticles.

We look forward to receiving your contributions.

Dr. Paulina Żeliszewska
Dr. Monika Wasilewska
Guest Editors

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Keywords

  • functional nanoparticles
  • biomedical applications
  • drug delivery
  • multifunctionality
  • nanomedicine

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Published Papers (1 paper)

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Research

24 pages, 2615 KiB  
Article
Functionalized Silver Nanoparticles as Multifunctional Agents Against Gut Microbiota Imbalance and Inflammation
by Mihaela Stoyanova, Vera Gledacheva, Miglena Milusheva, Mina Todorova, Nikoleta Kircheva, Silvia Angelova, Iliyana Stefanova, Mina Pencheva, Yulian Tumbarski, Bela Vasileva, Kamelia Hristova-Panusheva, Zlatina Gospodinova, Natalia Krasteva, George Miloshev, Milena Georgieva and Stoyanka Nikolova
Nanomaterials 2025, 15(11), 815; https://doi.org/10.3390/nano15110815 - 28 May 2025
Viewed by 464
Abstract
Human pathogenic fungi are the source of various illnesses, including invasive, cutaneous, and mucosal infections. One promising solution is using nanoparticles (NPs) as an antifungal agent. The current study aims to assess the antimicrobial and antifungal effects of drug-loaded silver nanoparticles (AgNPs) with [...] Read more.
Human pathogenic fungi are the source of various illnesses, including invasive, cutaneous, and mucosal infections. One promising solution is using nanoparticles (NPs) as an antifungal agent. The current study aims to assess the antimicrobial and antifungal effects of drug-loaded silver nanoparticles (AgNPs) with previously reported mebeverine analogue (MA) as a potential drug candidate targeting gut microbiota and inflammation in the gastrointestinal tract. Density Functional Theory (DFT) calculations were conducted to identify possible mechanisms by which AgNPs could prevent microorganisms from growing. In vitro and ex vivo anti-inflammatory, in vitro antimicrobial, ex vivo spasmolytic activities, and in vitro hepatic cell morphology and proliferation of drug-loaded AgNPs were assessed. The drug-loaded AgNPs were considered to have promising antifungal activity against all tested fungal strains, Aspergillus niger, Penicillium chrysogenum, and Fusarium moniliforme, and yeasts, Candida albicans, Saccharomyces cerevisiae, and good antimicrobial activity against Gram-positive and Gram-negative bacterial strains. The results of in vitro and ex vivo determination of anti-inflammatory activity indicated that the drug-loaded AgNPs preserved MA’s anti-inflammatory activity and decreased inflammation. A similar effect was observed in spasmolytic activity measurements. Drug-loaded AgNPs also influenced the morphology and proliferation of hepatic cells, indicating a potential for improved gut and liver therapeutic efficacy. Each test was performed in triplicate, and the results were reported as mean values. Based on the results, drug-loaded AgNPs might be a promising antimicrobial agent, maintaining the MA’s potential as a spasmolytic and anti-inflammatory agent. Future in vivo and preclinical experiments will contribute to establishing the in vivo properties of drug-loaded AgNPs. Full article
(This article belongs to the Special Issue Synthesis of Functional Nanoparticles for Biomedical Applications)
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