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Nanomaterials
Special Issues
Advances in Nanotechnology for Medical Implants
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Advances in Nanotechnology for Medical Implants

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 29 August 2025 | Viewed by 696

Special Issue Editors

Dr. Csaba Balázsi

E-Mail Website
Guest Editor
Centre for Energy Research, Institute of Technical Physics and Materials Science, 1121 Budapest, Hungary
Interests: bioceramics; biomaterials; ceramic dispersion strengthened steels; ceramics and nanocomposites for high temperature and tribological applications; open structured funcional materials for sensorics; fibre polymers; composites and coatings
Special Issues, Collections and Topics in MDPI journals
Dr. Katalin Balázsi

E-Mail Website
Guest Editor
Centre for Energy Research, Institute of Technical Physics and Materials Science, 1121 Budapest, Hungary
Interests: bioceramic; thin films; TEM; ceramic composite
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue provides a current overview of the present applications of nanotechnology-based biomaterials in orthopedic implants, bone regeneration, bone tissue engineering, and its prospective future applications in drug delivery systems or smart scaffold fabrication. Nanomaterials with tailored bioactivity, biocompatibility, or biodegrability have great potential for use in medical implant designs and orthopedic applications due to their exceptional functional properties, capability to maintain drug release, or osseointegration and tissue regeneration. Moreover, nanotechnology-based biomaterials are able to mimic the features and hierarchical structure of native cortical or trabecular bones. They facilitate cell proliferation, decrease the rate of infection, and prevent biofilm formation, among other diverse functions. The emergence of nanostructured polymers, metals, ceramics, composites, and carbon materials has facilitated novel approaches in medical implant designs in orthopaedic research. Articles and review papers are invited to provide a concise opinion of the nanotechnology-based biomaterials that are utilized in orthopedics, covering metallic and nonmetallic nanomaterials.

Dr. Csaba Balázsi
Dr. Katalin Balázsi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanotechnology-based biomaterials
  • drug delivery systems
  • bioactive coatings
  • biocompatible nanocomposites
  • biodegradable materials
  • bone tissue engineering
  • novel scaffolds by additive manufacturing
  • surface modification of implants
  • bone regeneration
  • osteointegration
  • artificial intelligence in the medical implant industry

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Published Papers (1 paper)

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Research

14 pages, 4335 KiB  
Article
Impact of Atomic Layer-Deposited Hydroxyapatite-Coated Titanium on Expression of Focal Adhesion Molecules of Human Gingival Fibroblasts
by Nagat Areid, Faleh Abushahba, Sini Riivari, Elisa Närvä, Elina Kylmäoja, Mikko Ritala, Juha Tuukkanen, Pekka K. Vallittu and Timo O. Närhi
Nanomaterials 2025, 15(12), 887; https://doi.org/10.3390/nano15120887 - 8 Jun 2025
Viewed by 427
Abstract
This study investigated the impact of the nanocrystalline atomic layer-deposited hydroxyapatite (ALD-HA) coating of titanium (Ti) surface on the attachment and proliferation of human gingival fibroblasts (HGFs). Ti discs were divided into ALD-HA-coated and non-coated (NC) controls. HGFs were harvested from gingival biopsies [...] Read more.
This study investigated the impact of the nanocrystalline atomic layer-deposited hydroxyapatite (ALD-HA) coating of titanium (Ti) surface on the attachment and proliferation of human gingival fibroblasts (HGFs). Ti discs were divided into ALD-HA-coated and non-coated (NC) controls. HGFs were harvested from gingival biopsies of patients subjected to extraction of their third molar. The cells were cultivated on the Ti discs for 2 and 24 h to evaluate the initial cell attachment using confocal microscopy. Spreading of cells and the signals of focal adhesion proteins were measured. Moreover, the adhesion proteins vinculin and paxillin expression levels were evaluated using Western blot after 3 d of cultivation. In addition, the proliferation of HGF was assessed by cultivating the cells on Ti discs for 1, 3, and 7 d. Fibroblast spreading was significantly greater on ALD-HA surfaces than on NC surfaces after 2 h (p < 0.001). In addition, the signals of vinculin and paxillin were significantly higher on the ALD-HA than on the NC surfaces at 2 and 24 h. The confocal microscope analysis also revealed significantly higher expression of focal adhesion molecules on ALD-HA surfaces at both time points. Furthermore, the cell proliferation rate was significantly higher at d 3 (p = 0.022) and d 7 (p < 0.001) on the ALD-HA compared to the NC surfaces. These findings indicate that ALD-HA coating enhances focal adhesion formation, cell spreading, and proliferation on Ti surfaces, suggesting its potential to improve gingival tissue attachment to Ti implant surfaces. Full article
(This article belongs to the Special Issue Advances in Nanotechnology for Medical Implants)
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