Nanomaterials

Journal Browser

► Journal Browser

Special Issue Information

Dear Colleagues,

Nanotechnology opens new avenues in the biomedical research field, such as diagnosis, drug delivery, targeted therapy, and so on. Nanomaterials with multiple features have various potential characteristics that make them a suitable candidate for biomedical applications. Increased loading capacity, enhanced surface area, capability of reactive oxygen species induction, as well as aptitude for surface functionalization are among the most important features of these nanomaterials. An accumulating body of recent studies have been reported the high efficacy of nanomaterials in bioimaging, biosensing, gene delivery, drug delivery, photothermal therapy, hyperthermia, combination therapy, and concurrent therapy and diagnostics (theranostics). Therefore, this Special Issue aims to elaborate on the critical function of nanomaterials in biomedical research.

This Special Issue of Nanomaterials on “Nanomaterials for Diagnosis, Drug Delivery and Targeted Therapy” aims to collect original research and review articles that highlight synthesis, modification, design, properties, and applications in various areas related to biomedical nanomaterials. We would like to invite scientists and engineers from diverse and multidisciplinary fields with different technological backgrounds to contribute their works to this Special Issue.

Drug delivery
Targeted therapy
Cancer nanotherapy
Nanocarriers
Diagnosis
Bioimaging
Biosensing
Biomedical nanomaterials

Dr. Abdul K. Parchur
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

drug delivery
targeted therapy
cancer nanotherapy
nanocarriers
diagnosis
bioimaging
biosensing
biomedical nanomaterials

Published Papers (2 papers)

Download All Papers

Research

Jump to: Review

16 pages, 2742 KiB

Open AccessArticle

Effect of an NGR Peptide on the Efficacy of the Doxorubicin Phospholipid Delivery System

by Lyubov V. Kostryukova, Yulia A. Tereshkina, Elena G. Tikhonova, Yulia Yu. Khudoklinova, Daria V. Bobrova, Alisa M. Gisina, Galina E. Morozevich, Veronica V. Pronina, Tatiana V. Bulko and Victoria V. Shumyantseva

Nanomaterials 2023, 13(15), 2229; https://doi.org/10.3390/nano13152229 - 01 Aug 2023

Cited by 2 | Viewed by 965

Abstract

This study is a continuation of an investigation into the effect of a targeted component, a peptide with an NGR, on the properties of the previously developed doxorubicin phospholipid delivery system. The NGR peptide has an affinity for aminopeptidase N (known as the CD13 marker on the membrane surface of tumor cells) and has been extensively used to target drug delivery systems. This article presents the results of a study investigating the physical properties of the phospholipid composition with and without the peptide chain: particle size, zeta potential, stability in fluids, and dependence of doxorubicin release from nanoparticles at different pH levels (5.0, 6.5, 7.4). The cytotoxic effect of the compositions has also been shown to depend on the dose of the drug used for incubation, the presence of the targeted component in the composition, and the time of incubation time of the substances. There was a significant difference in the cytotoxic effect on HT-1080 (CD13-positive) and MCF-7 (CD13-negative) cells. Cell death pathway analysis has shown that death occurred mainly by apoptosis. We also present data on the effect of doxorubicin embedded in phospholipid nanoparticles with the targeted peptide on DNA assessed by differential pulse voltammetry, the mechanism of action being electrostatic interactions. The interactions of native dsDNA with doxorubicin encapsulated in phospholipid nanoparticles with the targeted peptide were studied electrochemically by differential pulse voltammetry. Here, we have highlighted that the targeted peptide in the doxorubicin composition moved specific interaction of the drug with dsDNA from intercalative mode to electrostatic interactions. Full article

(This article belongs to the Special Issue Nanomaterials for Diagnosis, Drug Delivery and Targeted Therapy)

► Show Figures

Figure 1

Review

Jump to: Research

33 pages, 2105 KiB

Open AccessReview

Passing of Nanocarriers across the Histohematic Barriers: Current Approaches for Tumor Theranostics

by Kamil Gareev, Ruslana Tagaeva, Danila Bobkov, Natalia Yudintceva, Daria Goncharova, Stephanie E. Combs, Artem Ten, Konstantin Samochernych and Maxim Shevtsov

Nanomaterials 2023, 13(7), 1140; https://doi.org/10.3390/nano13071140 - 23 Mar 2023

Cited by 3 | Viewed by 1932

Abstract

Over the past several decades, nanocarriers have demonstrated diagnostic and therapeutic (i.e., theranostic) potencies in translational oncology, and some agents have been further translated into clinical trials. However, the practical application of nanoparticle-based medicine in living organisms is limited by physiological barriers (blood–tissue barriers), which significantly hampers the transport of nanoparticles from the blood into the tumor tissue. This review focuses on several approaches that facilitate the translocation of nanoparticles across blood–tissue barriers (BTBs) to efficiently accumulate in the tumor. To overcome the challenge of BTBs, several methods have been proposed, including the functionalization of particle surfaces with cell-penetrating peptides (e.g., TAT, SynB1, penetratin, R8, RGD, angiopep-2), which increases the passing of particles across tissue barriers. Another promising strategy could be based either on the application of various chemical agents (e.g., efflux pump inhibitors, disruptors of tight junctions, etc.) or physical methods (e.g., magnetic field, electroporation, photoacoustic cavitation, etc.), which have been shown to further increase the permeability of barriers. Full article

(This article belongs to the Special Issue Nanomaterials for Diagnosis, Drug Delivery and Targeted Therapy)

► Show Figures