Versatility of G-quadruplexes

Dear Colleagues,

G-quadruplex, secondary tetraplex structures formed by DNA and RNA rich in guanosine residues, has gained interest due to its biological function as well as biomedical and bioanalytical applications. Sequences able to form G-quadruplexes were found in telomeres, promotors and other regulatory domains. The formation of G-quadruplexes was also visualized in vivo. The ongoing research in this field focuses on the understanding of the G-quadruplex function in genome as well as other nucleic acids in the cell (e.g., microRNA). On the other hand, G-quadruplexes are used in the development of many bioassays thanks to their outstanding abilities, such as structure switching (e.g., under the influence of cations), the formation of many aptamers, and the formation of DNAzyme with peroxidase activity. This versatility makes G-quadruplex an eligible target for biomedical and bioanalytical research.

Prof. Dr. Bernard Juskowiak
Dr. Anna Renata Dembska
Dr. Anna S. Kichkailo
Dr. Joanna Kosman
Collection Editors

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