H2S and derived Reactive Sulfur Species Signalling

Dear Colleagues,

The biological importance of the small cellular signalling molecule H₂S has been well established in the last two decades, especially in regard to cardiovascular health and disease.  Inorganic polysulfides (H₂S_x, x ≥ 2) are considered as derivative signalling agents that result from endogenous H₂S oxidation, but other reactive sulfur species (RSS) including small sulfur oxoacids may also play a role. All of these potential signalling agents are primitive chemical molecules, i.e., sulfur chains composed exclusively of sulfur with hydrogens or hydroxyls at the termini. The so-called small oxoacids of sulfur (SOS) are new players in the field of sulfur biology but seem to be important intermediates in polysulfide formation, posttranslational protein modifications, and redox signalling. There has been notable recent progress in the redox biology and analytical detection of both the polysulfides and the sulfur-oxides; thus, it is an opportune time to take stock of the present knowledge and look to future developments. This Special Issue is aimed at chemical, analytical, and biological studies that will help define the targets and mechanisms of action of these unique species. 

Prof. Dr. Patrick J. Farmer
Guest Editor

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• H2S signaling
• cellular thiolstat
• redox modulation
• reactive sulfur species
• polysulfides
• sulfur oxoacids