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Molecules 2018, 23(3), 628; https://doi.org/10.3390/molecules23030628

Selenides and Diselenides: A Review of Their Anticancer and Chemopreventive Activity

1
Instituto de Química Orgánica General, Consejo Superior de Investigaciones Científicas (IQOG, CSIC), Juan de la Cierva 3, 28006 Madrid, Spain
2
Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, Campus B2 1, D-66123 Saarbruecken, Germany
3
Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland
*
Author to whom correspondence should be addressed.
Received: 3 January 2018 / Revised: 7 March 2018 / Accepted: 9 March 2018 / Published: 10 March 2018
(This article belongs to the Special Issue Small Molecule Catalysts with Therapeutic Potential)
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Abstract

Selenium and selenocompounds have attracted the attention and the efforts of scientists worldwide due to their promising potential applications in cancer prevention and/or treatment. Different organic selenocompounds, with diverse functional groups that contain selenium, have been reported to exhibit anticancer and/or chemopreventive activity. Among them, selenocyanates, selenoureas, selenoesters, selenium-containing heterocycles, selenium nanoparticles, selenides and diselenides have been considered in the search for efficiency in prevention and treatment of cancer and other related diseases. In this review, we focus our attention on the potential applications of selenides and diselenides in cancer prevention and treatment that have been reported so far. The around 80 selenides and diselenides selected herein as representative compounds include promising antioxidant, prooxidant, redox-modulating, chemopreventive, anticancer, cytotoxic and radioprotective compounds, among other activities. The aim of this work is to highlight the possibilities that these novel organic selenocompounds can offer in an effort to contribute to inspire medicinal chemists in their search of new promising derivatives. View Full-Text
Keywords: selenium; selenocompounds; selenides; diselenides; antioxidants; chemoprevention; anticancer compounds; cytotoxicity; cytostaticity selenium; selenocompounds; selenides; diselenides; antioxidants; chemoprevention; anticancer compounds; cytotoxicity; cytostaticity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Álvarez-Pérez, M.; Ali, W.; Marć, M.A.; Handzlik, J.; Domínguez-Álvarez, E. Selenides and Diselenides: A Review of Their Anticancer and Chemopreventive Activity. Molecules 2018, 23, 628.

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