Special Issue "Think Yellow: Reactive Sulfur Species in Redox Biology, Medicine and Agriculture"
Deadline for manuscript submissions: closed (30 September 2016).
Interests: bioorganic chemistry; catalytic sensor/effector agents; epistemology; intracellular diagnostics; nanotechnology; natural products; reactive sulfur and selenium species; redox regulation via the cellular thiolstat
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Interests: reactive sulfur species; redox drugs; nitric oxide; cancer
Research conducted during the last couple of decades has shown that Reactive Sulfur Species (RSS), i.e., molecules with one or more chemically-reactive sulfur atoms, play a major role in Biology. Such sulfur-containing reactive species embrace a wide range of chemically diverse compounds, each with its own, facet-rich reactivity and biochemical activity. Here, we find rather exotic molecules, such as organic di- and polysulfanes, H2S and inorganic polysulfides, thiosulfinates, thiosulfonates and hypothiocyanous acid, to name just a few. From a chemical perspective, most of these molecules are oxidizing, electrophilic species, often selectively modifying thiol groups in cysteine proteins belonging to the regulatory network shaping the cellular thiolstat; while others, such as H2S, may act as reductants. Indeed, RSS are omnipresent in Biology, and many of them exhibit interesting redox modulating properties which ultimately may be used in the context of chemoprevention, the treatment of certain diseases (e.g., inflammatory and infectious diseases, cancer) and, in the case of plant derived products, as ecologically friendly “green” phytoprotectants in Agriculture.
The concept of RSS was explicitly introduced into the literature in 2001 and, 15 years onwards, RSS are now center stage in many fields of research. Recent developments in RSS research span natural products chemistry and biochemistry, drug development, synthetic sulfur chemistry, nanotechnology and analytics. Many of these discoveries begin to have a significant role in shaping the fields of nutrition, ageing, control of the microbiota, drug and pesticide development, to highlight but a few emerging applications.
This Special Issue, therefore, aims to showcase the diversity and impact of RSS on different aspects of Biology, especially on human and animal health, and to emphasize potential RSS innovations in agriculture. It also strives to explore why those RSS are—often selectively—active, and how they interact with their cellular targets. Eventually, a more contemporary definition of RSS may emerge the in the light of recent developments, which will benchmark those chemically yellow, yet biologically colourful species, for subsequent years to come.
Prof. Claus Jacob
Dr. Gregory Ian Giles
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Reactive Sulfur Species (RSS)
- redox active secondary metabolites
- Cellular Thiolstat
- redox modulating drugs
- sulfur biochemistry
- redox signaling