Repositioning Natural Products in Drug Discovery
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 25153
Special Issue Editors
Interests: computational approaches; drug discovery; drug design; molecular modeling; computational chemistry; virtual screening
Special Issues, Collections and Topics in MDPI journals
Interests: natural products; drug discovery; medicinal chemistry; hyperproliferative disorders; central nervous system (CNS) pathologies
Special Issues, Collections and Topics in MDPI journals
Interests: computational approaches; drug discovery; drug design; molecular modeling; computational chemistry; virtual screening
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We invite you to contribute to this Special Issue of Molecules entitled “Repositioning Natural Products in Drug Discovery”. Drug repurposing has become one of the most popular and successful strategies to reduce the failures typically associated with drug discovery. Drug repurposing involves the identification of novel targets and different therapeutic uses of drugs and drug candidates under development. As such, preclinical development and optimization issues, such as adverse toxicology profiles, can be prevented. Although most drug repurposing success stories derive from serendipity, research efforts are currently directed toward predicting new repurposing possibilities on rational grounds. Remarkably, while most drug repurposing studies rely on synthetic compounds, significant opportunities from natural products are expected to come into play. Natural products are characterized by unique and favorable properties, great structural diversity, and the provision of valuable chemical entities for drug discovery campaigns.
This Special Issue will focus on experimental and computational approaches in the research area of natural products and repurposing, including studies on, but not limited to, the identification of new targets of natural compounds, the discovery of bioactive natural and semi-synthetic compounds, their isolation and characterization, dereplication of natural extracts, analysis of structure–activity relationships of natural products, and in silico screening.
Prof. Giulio Rastelli
Prof. Federica Pellati
Dr. Luca Pinzi
Guest Editors
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