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Special Issue "Polyketides-II"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 March 2019

Special Issue Editor

Guest Editor
Prof. Dr. Kira J. Weissman

Molecular and Structural Enzymology Group, UMR 7365 CNRS-UL : IMoPA, Lorraine University, Faculté de médecine, Batiment Biopôle, 9 avenue de la Forêt de Haye, CS 50184, 54506 Vandoeuvre-lès-Nancy CEDEX, France
Website | E-Mail
Interests: molecular enzymology; structural biology and genetic engineering of polyketide synthases (PKS) and hybrid PKS-nonribosomal peptide synthetases (NRPS)

Special Issue Information

Dear Colleagues,

The study of polyketide synthase (PKSs) enzymes has grown over the last quarter-century into a dynamic area, encompassing a multiplicity of complementary approaches, from metagenomics to microbiology, in vitro enzymology to structural biology, and molecular genetics to synthetic biology. A striking picture that has emerged is of the extraordinary diversity of these systems and their capacity to intersect with other types of biosynthetic pathways, even as the roles played by the polyketide metabolites for their produces often remain obscure. This second Special Issue aims to encompass papers at the forefront of research in the field, by treating in particular the following topical issues: Novel types of PKS domain enzymology; new types of biosynthetic pathways in which PKSs are implicated; efforts to discover new polyketides by exploiting advances in genome mining (identification of novel producers, activation of silent pathways, heterologous expression, etc.); new insights into PKS function gleaned from structural biology and allied biophysical approaches; emerging information on the functions of these metabolites in the environment (chemical ecology); and novel synthetic biology approaches towards manipulating PKSs towards the generation of analogs for biological testing.

As Guest Editor, I cordially invite researchers to submit their work relevant to these questions to this Special Issue of Molecules.

Prof. Dr. Kira Weissman
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • biosynthesis
  • polyketide natural products
  • polyketide synthases
  • mechanistic enzymology
  • genetic engineering
  • structural biology
  • genome mining
  • chemical ecology

Published Papers

This special issue is now open for submission.
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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