E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Special Issue "Xanthones: Themed Issue in Honor of Professor Madalena Pinto on the Occasion of Her 70th Birthday"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 31 December 2018

Special Issue Editors

Guest Editor
Prof. Dr. Maria Emília de Sousa

1. Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências, Químicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira 228, 4050-313, Porto, Portugal
2. Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Universidade do Porto, Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, S/N 4450-208 Matosinhos, Portugal
Website | E-Mail
Interests: medicinal chemistry; organic synthesis; heterocycles, P-glycoprotein; anticancer; anticoagulants; chiral drugs; marine natural products
Guest Editor
Prof. Dr. Honorina Cidade

1. Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal
2. Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Universidade do Porto, Edifício do Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n | 4050-208 Matosinhos, Portugal
Website | E-Mail
Interests: medicinal chemistry; organic synthesis; natural products; heterocycles; anticancer; antioxidant
Guest Editor
Prof. Dr. Carlos Manuel Afonso

1 Laboratório de Química Orgânica e Farmacêutica, Dep. Ciências Químicas, Faculdade de Farmácia da Universidade do Porto, Rua Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal
2 CIIMAR: Centro Interdisciplinar de Investigação Marinha e Ambiental da Universidade do Porto, Rua dos Bragas, 289, 4050-123 Porto, Portugal
Website | E-Mail
Interests: medicinal chemistry; organic synthesis; pharmaceutical analysis; ADMET prediction; natural products

Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to Prof. Madalena Pinto (http://www.madalenapinto.com), who is currently Full Professor at the Department of Chemistry, Faculty of Pharmacy at the University of Porto (FFUP), on the occasion of her 70th birthday (to be celebrated on 15 September, 2018), and in honor of her many achievements in Medicinal Chemistry, and, particularly, her outstanding research contributions in the fields concerning “Xanthones”.

Xanthones are a class of oxygenated heterocyclic compounds with a dibenzo-γ-pyrone scaffold which have long been recognized for their wide range of biological and pharmacological activities.

Professor Madalena Pinto is undoubtedly one of the leading Medicinal Chemists in Portugal and a well-known personality in the scientific community. She graduated in the Faculty of Pharmacy at the University of Porto, and carried out her doctoral studies in the University of São Paulo, Brazil, with Professor Otto Gottlieb (nominated for the Nobel Prize in Chemistry in 1999). She was the Coordinator of meaningful Portuguese Research Centers, such as CEQOFFUP-FCT- R&D 226 (from 1996 to 2007) and “Center of Medicinal Chemistry of the University of Porto” (CEQUIMED- UP, FCT I&D 4040, from 2007–2015). Professor Madalena Pinto was the only woman as Director (1982–1984) of the Faculty of Pharmacy of the University of Porto so far. She also created the First Course of Pharmaceutical Sciences of the Instituto Superior das Ciências da Saúde-Norte (CESPU) and was the Director of the first PhD Course in Pharmaceutical Sciences of FFUP (2009/2010) and Member of the Committee of Therapeutic Chemistry of the Portuguese Society of Chemistry (2012–2015). Currently, she is Team Leader of the Group of Natural Products and Medicinal Chemistry at Interdisciplinary Centre of Marine and Environmental Research (CIIMAR) (2014-). Professor Madalena Pinto has been the head of the Laboratory of Organic and Pharmaceutical Chemistry of the FFUP since 1985 and is Director of the first Master Course in Pharmaceutical Chemistry of FFUP. She is also Adjunct Professor of Kasetsart University. Bangkok, Thailand. Professor Madalena Pinto is the author of more than two hundred publications, with more than 3200 citations, and an h-index of 30. Her research interests embrace broad areas such as Natural Products and Medicinal Chemistry as well as more specific related with organic synthesis, chirality, and analytic applications of molecular recognition. In her outstanding research, Professor Madalena Pinto has contributed significantly for revealing diverse aspects of chemistry and biological activities of a large number of xanthone derivatives, combining successfully organic synthesis with principles of natural products.

Professor Madalena Pinto supervised a large number of postgraduate and post-doctoral students, many of whom are currently holding academic positions in Portugal and around the world. During almost 50 years of Professorship she has been truly dedicated to teaching Chemistry at all levels, being the author of several pedagogical publications in the field of Medicinal Chemistry.

On behalf of many colleagues, students and collaborators, we are honored to dedicate this Special Issue to Madalena Pinto, and wish Professor Madalena good health, much energy and further success in her scientific life and hope for lasting cooperation in Medicinal Chemistry research and education.  

Prof. Dr. Maria Emília de Sousa
Prof. Dr. Honorina Cidade
Prof. Dr. Carlos Manuel Afonso
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • xanthones
  • natural products
  • chirality
  • O-heterocycles

Published Papers (2 papers)

View options order results:
result details:
Displaying articles 1-2
Export citation of selected articles as:

Research

Open AccessArticle Lichen Xanthones as Models for New Antifungal Agents
Molecules 2018, 23(10), 2617; https://doi.org/10.3390/molecules23102617
Received: 20 September 2018 / Revised: 4 October 2018 / Accepted: 9 October 2018 / Published: 12 October 2018
PDF Full-text (1271 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Due to the emergence of multidrug-resistant pathogenic microorganisms, the search for new antimicrobial compounds plays an important role in current medicinal chemistry research. Inspired by lichen antimicrobial xanthones, a series of novel chlorinated xanthones was prepared using five chlorination methods (Methods A–E) to
[...] Read more.
Due to the emergence of multidrug-resistant pathogenic microorganisms, the search for new antimicrobial compounds plays an important role in current medicinal chemistry research. Inspired by lichen antimicrobial xanthones, a series of novel chlorinated xanthones was prepared using five chlorination methods (Methods A–E) to obtain different patterns of substitution in the xanthone scaffold. All the synthesized compounds were evaluated for their antimicrobial activity. Among them, 3-chloro-4,6-dimethoxy-1-methyl-9H-xanthen-9-one 15 showed promising antibacterial activity against E. faecalis (ATCC 29212 and 29213) and S. aureus ATCC 29213. 2,7-Dichloro-3,4,6-trimethoxy-1-methyl-9H-xanthen-9-one 18 revealed a potent fungistatic and fungicidal activity against dermatophytes clinical strains (T. rubrum, M. canis, and E. floccosum (MIC = 4–8 µg/mL)). Moreover, when evaluated for its synergistic effect for T. rubrum, compound 18 exhibited synergy with fluconazole (ΣFIC = 0.289). These results disclosed new hit xanthones for both antibacterial and antifungal activity. Full article
Figures

Figure 1

Open AccessCommunication The Design and Synthesis of N-Xanthone Benzenesulfonamides as Novel Phosphoglycerate Mutase 1 (PGAM1) Inhibitors
Molecules 2018, 23(6), 1396; https://doi.org/10.3390/molecules23061396
Received: 13 May 2018 / Revised: 1 June 2018 / Accepted: 4 June 2018 / Published: 8 June 2018
PDF Full-text (5770 KB) | HTML Full-text | XML Full-text
Abstract
Upregulation of phosphoglycerate mutase 1 (PGAM1) has been identified as one common phenomenon in a variety of cancers. Inhibition of PGAM1 provides a new promising therapeutic strategy for cancer treatment. Herein, based on our previous work, a series of new N-xanthone benzenesulfonamides
[...] Read more.
Upregulation of phosphoglycerate mutase 1 (PGAM1) has been identified as one common phenomenon in a variety of cancers. Inhibition of PGAM1 provides a new promising therapeutic strategy for cancer treatment. Herein, based on our previous work, a series of new N-xanthone benzenesulfonamides were discovered as novel PGAM1 inhibitors. The representative molecule 15h, with an IC50 of 2.1 μM, showed an enhanced PGAM1 inhibitory activity and higher enzyme inhibitory specificity compared to PGMI-004A, as well as a slightly improved antiproliferative activity. Full article
Figures

Graphical abstract

Back to Top