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Nature-Inspired Antitumor Agents, 2nd Edition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 183

Special Issue Editor

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Guest Editor
Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira n° 228, 4050-313 Porto, Portugal
Interests: medicinal chemistry; organic synthesis; drug discovery; anticancer activity; antimicrobial activity; chiral drugs; natural products
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Special Issue Information

Dear Colleagues,

Medicinal chemistry in the twenty-first century has undergone innovative developments due to revolutions in biotechnology and informatics. These advances are mainly within the lead optimization process, but a very significant portion of these leads will continue to contain molecules which originate from natural products (NPs). The diversity of species from terrestrial plants, animals, microorganisms, and marine organisms results in a multitude of secondary metabolites with novel chemical structures and innovative mechanisms of action.

This renaissance of NPs is most allied with total synthesis, semi-synthesis, and analogue-based design. Nevertheless, other biotechnology and cheminformatics approaches are being used to investigate leads from nature. Among the activities of NPs, antitumor activity stands out. NPs like doxorubicin and taxol have their place in chemotherapy alongside new immunotherapies.

This Special Issue focuses on recent breakthroughs, which will help develop new antitumor agents inspired by the variety of NPs emerging as chemotherapeutics, and which intends to collect the state of the art with original research and review articles that consider NP analogues as potential antitumor drug candidates. Unique topics are welcomed.

Dr. Honorina Cidade
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • natural products
  • antitumor activity
  • NPs analogues-based design

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