Next Article in Journal
Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing
Next Article in Special Issue
Structures, Activities and Drug-Likeness of Anti-Infective Xanthone Derivatives Isolated from the Marine Environment: A Review
Previous Article in Journal
Solid-Phase Synthesis and Circular Dichroism Study of β-ABpeptoids
Previous Article in Special Issue
New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 24
Issue 1
10.3390/molecules24010180
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Carboxyxanthones: Bioactive Agents and Molecular Scaffold for Synthesis of Analogues and Derivatives

by
João Ribeiro
1,
Cláudia Veloso
1,
Carla Fernandes
1,2,*,
Maria Elizabeth Tiritan
1,2,3 and
Madalena M. M. Pinto
1,2,*
1
Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal
2
Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Edifício do Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4050-208 Matosinhos, Portugal
3
Cooperativa de Ensino Superior, Politécnico e Universitário (CESPU), Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde (IINFACTS), Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal
*
Authors to whom correspondence should be addressed.
Molecules 2019, 24(1), 180; https://doi.org/10.3390/molecules24010180
Submission received: 19 December 2018 / Revised: 31 December 2018 / Accepted: 2 January 2019 / Published: 5 January 2019
(This article belongs to the Special Issue Xanthones: Themed Issue in Honor of Professor Madalena Pinto on the Occasion of Her 70th Birthday)
Browse Figures
Versions Notes

Abstract

Xanthones represent a structurally diverse group of compounds with a broad range of biological and pharmacological activities, depending on the nature and position of various substituents in the dibenzo-γ-pyrone scaffold. Among the large number of natural and synthetic xanthone derivatives, carboxyxanthones are very interesting bioactive compounds as well as important chemical substrates for molecular modifications to obtain new derivatives. A remarkable example is 5,6-dimethylxanthone-4-acetic acid (DMXAA), a simple carboxyxanthone derivative, originally developed as an anti-tumor agent and the first of its class to enter phase III clinical trials. From DMXAA new bioactive analogues and derivatives were also described. In this review, a literature survey covering the report on carboxyxanthone derivatives is presented, emphasizing their biological activities as well as their application as suitable building blocks to obtain new bioactive derivatives. The data assembled in this review intends to highlight the therapeutic potential of carboxyxanthone derivatives and guide the design for new bioactive xanthone derivatives.
Keywords: xanthone scaffold; carboxyxanthone derivatives; carboxyxanthone analogues; bioactivities xanthone scaffold; carboxyxanthone derivatives; carboxyxanthone analogues; bioactivities

Share and Cite

MDPI and ACS Style

Ribeiro, J.; Veloso, C.; Fernandes, C.; Tiritan, M.E.; Pinto, M.M.M. Carboxyxanthones: Bioactive Agents and Molecular Scaffold for Synthesis of Analogues and Derivatives. Molecules 2019, 24, 180. https://doi.org/10.3390/molecules24010180

AMA Style

Ribeiro J, Veloso C, Fernandes C, Tiritan ME, Pinto MMM. Carboxyxanthones: Bioactive Agents and Molecular Scaffold for Synthesis of Analogues and Derivatives. Molecules. 2019; 24(1):180. https://doi.org/10.3390/molecules24010180

Chicago/Turabian Style

Ribeiro, João, Cláudia Veloso, Carla Fernandes, Maria Elizabeth Tiritan, and Madalena M. M. Pinto. 2019. "Carboxyxanthones: Bioactive Agents and Molecular Scaffold for Synthesis of Analogues and Derivatives" Molecules 24, no. 1: 180. https://doi.org/10.3390/molecules24010180

APA Style

Ribeiro, J., Veloso, C., Fernandes, C., Tiritan, M. E., & Pinto, M. M. M. (2019). Carboxyxanthones: Bioactive Agents and Molecular Scaffold for Synthesis of Analogues and Derivatives. Molecules, 24(1), 180. https://doi.org/10.3390/molecules24010180

Article Metrics

Back to TopTop