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Review

In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain

by 1 and 2,*
1
Department of Anesthesiology, Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
2
Department of Kinesiology and Nutrition Sciences, School of Integrated Health Sciences, University of Nevada, Las Vegas, NV 89154, USA
*
Author to whom correspondence should be addressed.
Academic Editor: H.P. Vasantha Rupasinghe
Molecules 2020, 25(5), 1171; https://doi.org/10.3390/molecules25051171
Received: 26 February 2020 / Accepted: 2 March 2020 / Published: 5 March 2020
(This article belongs to the Special Issue Biological Activity of Natural Substances and Their Derivatives)
Neuropathic pain is a common symptom and is associated with an impaired quality of life. It is caused by the lesion or disease of the somatosensory system. Neuropathic pain syndromes can be subdivided into two categories: central and peripheral neuropathic pain. The present review highlights the peripheral neuropathic models, including spared nerve injury, spinal nerve ligation, partial sciatic nerve injury, diabetes-induced neuropathy, chemotherapy-induced neuropathy, chronic constriction injury, and related conditions. The drugs which are currently used to attenuate peripheral neuropathy, such as antidepressants, anticonvulsants, baclofen, and clonidine, are associated with adverse side effects. These negative side effects necessitate the investigation of alternative therapeutics for treating neuropathic pain conditions. Flavonoids have been reported to alleviate neuropathic pain in murine models. The present review elucidates that several flavonoids attenuate different peripheral neuropathic pain conditions at behavioral, electrophysiological, biochemical and molecular biological levels in different murine models. Therefore, the flavonoids hold future promise and can be effectively used in treating or mitigating peripheral neuropathic conditions. Thus, future studies should focus on the structure-activity relationships among different categories of flavonoids and develop therapeutic products that enhance their antineuropathic effects. View Full-Text
Keywords: chemotherapy-induced peripheral neuropathy; chronic constriction injury; diabetic neuropathy; diabetic painful neuropathy; flavonoids; oxidative stress; partial sciatic nerve injury; peripheral neuropathy; spared nerve injury; spinal nerve ligation chemotherapy-induced peripheral neuropathy; chronic constriction injury; diabetic neuropathy; diabetic painful neuropathy; flavonoids; oxidative stress; partial sciatic nerve injury; peripheral neuropathy; spared nerve injury; spinal nerve ligation
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MDPI and ACS Style

Basu, P.; Basu, A. In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain. Molecules 2020, 25, 1171. https://doi.org/10.3390/molecules25051171

AMA Style

Basu P, Basu A. In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain. Molecules. 2020; 25(5):1171. https://doi.org/10.3390/molecules25051171

Chicago/Turabian Style

Basu, Paramita, and Arpita Basu. 2020. "In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain" Molecules 25, no. 5: 1171. https://doi.org/10.3390/molecules25051171

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