Next Article in Journal
Surface Treatment of Acetabular Cups with a Direct Deposition of a Composite Nanostructured Layer Using a High Electrostatic Field
Next Article in Special Issue
Induction of Apoptosis by Gluconasturtiin-Isothiocyanate (GNST-ITC) in Human Hepatocarcinoma HepG2 Cells and Human Breast Adenocarcinoma MCF-7 Cells
Previous Article in Journal
Phytochemical Composition and Biological Activity of Berries and Leaves from Four Romanian Sea Buckthorn (Hippophae Rhamnoides L.) Varieties
Previous Article in Special Issue
In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain

Natural Psychoplastogens As Antidepressant Agents

Center of Experimental Medicine, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia
Faculty of Medicine, Comenius University, 813 72 Bratislava, Slovakia
Author to whom correspondence should be addressed.
Academic Editor: Olga Pecháňová
Molecules 2020, 25(5), 1172;
Received: 31 December 2019 / Revised: 28 February 2020 / Accepted: 2 March 2020 / Published: 5 March 2020
(This article belongs to the Special Issue Biological Activity of Natural Substances and Their Derivatives)
Increasing prevalence and burden of major depressive disorder presents an unavoidable problem for psychiatry. Existing antidepressants exert their effect only after several weeks of continuous treatment. In addition, their serious side effects and ineffectiveness in one-third of patients call for urgent action. Recent advances have given rise to the concept of psychoplastogens. These compounds are capable of fast structural and functional rearrangement of neural networks by targeting mechanisms previously implicated in the development of depression. Furthermore, evidence shows that they exert a potent acute and long-term positive effects, reaching beyond the treatment of psychiatric diseases. Several of them are naturally occurring compounds, such as psilocybin, N,N-dimethyltryptamine, and 7,8-dihydroxyflavone. Their pharmacology and effects in animal and human studies were discussed in this article. View Full-Text
Keywords: depression; antidepressants; psychoplastogens; psychedelics; flavonoids depression; antidepressants; psychoplastogens; psychedelics; flavonoids
Show Figures

Figure 1

MDPI and ACS Style

Benko, J.; Vranková, S. Natural Psychoplastogens As Antidepressant Agents. Molecules 2020, 25, 1172.

AMA Style

Benko J, Vranková S. Natural Psychoplastogens As Antidepressant Agents. Molecules. 2020; 25(5):1172.

Chicago/Turabian Style

Benko, Jakub, and Stanislava Vranková. 2020. "Natural Psychoplastogens As Antidepressant Agents" Molecules 25, no. 5: 1172.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop