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Open AccessReview

Natural Psychoplastogens As Antidepressant Agents

1
Center of Experimental Medicine, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia
2
Faculty of Medicine, Comenius University, 813 72 Bratislava, Slovakia
*
Author to whom correspondence should be addressed.
Academic Editor: Olga Pecháňová
Molecules 2020, 25(5), 1172; https://doi.org/10.3390/molecules25051172
Received: 31 December 2019 / Revised: 28 February 2020 / Accepted: 2 March 2020 / Published: 5 March 2020
(This article belongs to the Special Issue Biological Activity of Natural Substances and Their Derivatives)
Increasing prevalence and burden of major depressive disorder presents an unavoidable problem for psychiatry. Existing antidepressants exert their effect only after several weeks of continuous treatment. In addition, their serious side effects and ineffectiveness in one-third of patients call for urgent action. Recent advances have given rise to the concept of psychoplastogens. These compounds are capable of fast structural and functional rearrangement of neural networks by targeting mechanisms previously implicated in the development of depression. Furthermore, evidence shows that they exert a potent acute and long-term positive effects, reaching beyond the treatment of psychiatric diseases. Several of them are naturally occurring compounds, such as psilocybin, N,N-dimethyltryptamine, and 7,8-dihydroxyflavone. Their pharmacology and effects in animal and human studies were discussed in this article. View Full-Text
Keywords: depression; antidepressants; psychoplastogens; psychedelics; flavonoids depression; antidepressants; psychoplastogens; psychedelics; flavonoids
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Benko, J.; Vranková, S. Natural Psychoplastogens As Antidepressant Agents. Molecules 2020, 25, 1172.

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