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Article

Beneficial Effects of Cornelian Cherries on Lipid Profile and NO/ROS Balance in Obese Zucker Rats: Comparison with CoQ10

1
Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia
2
1st Department of Internal Medicine, Medical Faculty of Comenius University, 811 07 Bratislava, Slovakia
3
Research Institute of Nutrition, 821 08 Bratislava, Slovakia
*
Author to whom correspondence should be addressed.
Academic Editor: Masahide Hamaguchi
Molecules 2020, 25(8), 1922; https://doi.org/10.3390/molecules25081922
Received: 1 March 2020 / Revised: 13 April 2020 / Accepted: 16 April 2020 / Published: 21 April 2020
(This article belongs to the Special Issue Biological Activity of Natural Substances and Their Derivatives)
Cornelian cherries (CCs) belong to promising anti-obesity substances. We aimed to study effects of coenzyme Q10 (CoQ10) and two varieties of CCs on lipid profile, ROS, and nitric oxide (NO) production in obese rats. Male Zucker rats were divided into the control group and groups treated with CoQ10 (30mg/kg/day), or CC varieties: Koralovij Marka (KM) and Wild Type (WT) (5 g/kg/day, n = 6 in each group) for 6 weeks. Blood pressure (BP), bodyweight, relative heart weight, and plasma lipid profile were determined. NOS activity and expressions of eNOS, SOD, and NADPH oxidase were determined in the left ventricle (LV) and aorta. Among CC groups, KM decreased bodyweight and WT relative heart weight. Neither CoQ10 nor CCs affected BP. CoQ10 did not affect lipid profile and NOS activity either in the LV or aorta. On the other hand, WT decreased cholesterol and LDL levels. KM and WT increased NOS activity in the aorta, while not affecting the activity in the LV. KM increased eNOS expression and did not affect ROS production, while WT increased SOD and decreased NADPH oxidase without affecting eNOS expressions in both tissues. In conclusion, CCs showed better beneficial effects than CoQ10 in all parameters studied. View Full-Text
Keywords: cornelian cherry; CoQ10; lipid profile; nitric oxide; reactive oxygen species; aorta; heart; obese Zucker rat cornelian cherry; CoQ10; lipid profile; nitric oxide; reactive oxygen species; aorta; heart; obese Zucker rat
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MDPI and ACS Style

Dayar, E.; Cebova, M.; Lietava, J.; Panghyova, E.; Pechanova, O. Beneficial Effects of Cornelian Cherries on Lipid Profile and NO/ROS Balance in Obese Zucker Rats: Comparison with CoQ10. Molecules 2020, 25, 1922. https://doi.org/10.3390/molecules25081922

AMA Style

Dayar E, Cebova M, Lietava J, Panghyova E, Pechanova O. Beneficial Effects of Cornelian Cherries on Lipid Profile and NO/ROS Balance in Obese Zucker Rats: Comparison with CoQ10. Molecules. 2020; 25(8):1922. https://doi.org/10.3390/molecules25081922

Chicago/Turabian Style

Dayar, Ezgi, Martina Cebova, Jan Lietava, Elena Panghyova, and Olga Pechanova. 2020. "Beneficial Effects of Cornelian Cherries on Lipid Profile and NO/ROS Balance in Obese Zucker Rats: Comparison with CoQ10" Molecules 25, no. 8: 1922. https://doi.org/10.3390/molecules25081922

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