Vasodilators: New Insights

A special issue of Pathophysiology (ISSN 1873-149X).

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 4240

Special Issue Editor


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Guest Editor
Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovakia
Interests: nitric oxide; polyphenolic compounds; cardiovascular system; hypertension; metabolic syndrome
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Special Issue Information

Dear Colleagues,

Vasodilators have been known for 120 years and yet our knowledge of them is still insufficient for successfully treating cardiovascular diseases, hypertension, angina pectoris, metabolic syndrome and other diseases requiring improved vasodilation. We, therefore, invite you to publish your latest results on the molecular nature, mechanisms, modifiability, effects and therapeutic possibilities of endogenous vasodilators, as well as the drugs that belong to them. Our Special Issue is mainly devoted to original knowledge in the field of c-AMP-, c-GMP- and hyperpolarization-mediated vasodilation, and PDE5 inhibitors and potassium channel openers, to central vasomotor control mechanisms, cold-induced vasodilation and other mechanisms of vasodilation. The Special Issue further focuses on modifiers of vasodilatory mechanisms, such as polyphenolic substances and many antioxidants; the targeted delivery of vasodilators, e.g., through nanoparticles; potential new vasodilators; and new perspectives on treatment options. Within this Special Issue, original articles, experimental results, clinical studies and more-extensive reviews will be published. We look forward to your contributions and cooperation.

Dr. Olga Pecháňová
Guest Editor

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Keywords

  • cardiovascular diseases
  • arteries
  • vasodilation
  • blood pressure
  • prostacyclin
  • nitric oxide
  • adenosine
  • hyperpolarization
  • polyphenolic substances
  • nanoparticles

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Published Papers (1 paper)

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Research

7 pages, 562 KiB  
Article
Circulating Levels of Endothelin-1 and Big Endothelin-1 in Patients with Essential Hypertension
by Krasimir Kostov and Alexander Blazhev
Pathophysiology 2021, 28(4), 489-495; https://doi.org/10.3390/pathophysiology28040031 - 25 Oct 2021
Cited by 6 | Viewed by 3124
Abstract
The role of endothelin-1 (ET-1) in the pathogenesis of hypertension (HTN) is not clearly established. There is evidence that its circulating levels are elevated in some forms of experimental and human HTN, but this was not a consistent finding. Based on these controversial [...] Read more.
The role of endothelin-1 (ET-1) in the pathogenesis of hypertension (HTN) is not clearly established. There is evidence that its circulating levels are elevated in some forms of experimental and human HTN, but this was not a consistent finding. Based on these controversial data, we tested serum levels of ET-1 and Big ET-1 (the precursor of ET-1) in patients with essential HTN, comparing the results with those of healthy normotensive controls. The levels of ET-1 and Big ET-1 were measured by ELISA. Our results in patients with essential HTN showed that the mean levels of ET-1 (5.01 ± 2.1 pg/mL) were significantly higher (F = 6.34, p = 0.0144) than the mean levels in the control group (3.2 ± 1.0 pg/mL). The levels of Big ET-1 in patients with essential HTN (0.377 ± 0.1 pmol/L) were similar to those in the control group (0.378 ± 0.07 pmol/L) and did not differ significantly (F = 0.00, p = 0.9531). These data suggest that ET-1, but not Big ET-1, may play an important role in the pathogenesis of primary HTN. Full article
(This article belongs to the Special Issue Vasodilators: New Insights)
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