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Iridoids: Research Advances in Their Phytochemistry, Biological Activities, and Pharmacokinetics

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Baotou Medical College, Baotou 014060, Inner Mongolia, China
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Faculty of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia, China
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Inner Mongolia Key Laboratory of Traditional Chinese Medicine Resources, Baotou Medical College, Baotou 014060, Inner Mongolia, China
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Inner Mongolia Institute of Traditional Chinese Medicine, Hohhot 010020, Inner Mongolia, China
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Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2020, 25(2), 287; https://doi.org/10.3390/molecules25020287 (registering DOI)
Received: 27 November 2019 / Revised: 28 December 2019 / Accepted: 8 January 2020 / Published: 10 January 2020
(This article belongs to the Special Issue Biological Activity of Natural Substances and Their Derivatives)
Iridoids are a class of active compounds that widely exist in the plant kingdom. In recent years, with advances in phytochemical research, many compounds with novel structure and outstanding activity have been identified. Iridoid compounds have been confirmed to mainly exist as the prototype and aglycone and Ι and II metabolites, by biological transformation. These metabolites have been shown to have neuroprotective, hepatoprotective, anti-inflammatory, antitumor, hypoglycemic, and hypolipidemic activities. This review summarizes the new structures and activities of iridoids identified locally and globally, and explains their pharmacokinetics from the aspects of absorption, distribution, metabolism, and excretion according to the differences in their structures, thus providing a theoretical basis for further rational development and utilization of iridoids and their metabolites. View Full-Text
Keywords: iridoids; phytochemistry; biological activities; pharmacokinetics iridoids; phytochemistry; biological activities; pharmacokinetics
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MDPI and ACS Style

Wang, C.; Gong, X.; Bo, A.; Zhang, L.; Zhang, M.; Zang, E.; Zhang, C.; Li, M. Iridoids: Research Advances in Their Phytochemistry, Biological Activities, and Pharmacokinetics. Molecules 2020, 25, 287.

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