Next Article in Journal
Phytochemical Characterization and In Vitro Anti-Inflammatory, Antioxidant and Antimicrobial Activity of Combretum Collinum Fresen Leaves Extracts from Benin
Previous Article in Journal
The Influence of Ionic Liquids on the Effectiveness of Analytical Methods Used in the Monitoring of Human and Veterinary Pharmaceuticals in Biological and Environmental Samples—Trends and Perspectives
Previous Article in Special Issue
Quercetin Exerts Age-Dependent Beneficial Effects on Blood Pressure and Vascular Function, But Is Inefficient in Preventing Myocardial Ischemia-Reperfusion Injury in Zucker Diabetic Fatty Rats
Open AccessReview

Iridoids: Research Advances in Their Phytochemistry, Biological Activities, and Pharmacokinetics

Baotou Medical College, Baotou 014060, Inner Mongolia, China
Faculty of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia, China
Inner Mongolia Key Laboratory of Traditional Chinese Medicine Resources, Baotou Medical College, Baotou 014060, Inner Mongolia, China
Inner Mongolia Institute of Traditional Chinese Medicine, Hohhot 010020, Inner Mongolia, China
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2020, 25(2), 287; (registering DOI)
Received: 27 November 2019 / Revised: 28 December 2019 / Accepted: 8 January 2020 / Published: 10 January 2020
(This article belongs to the Special Issue Biological Activity of Natural Substances and Their Derivatives)
Iridoids are a class of active compounds that widely exist in the plant kingdom. In recent years, with advances in phytochemical research, many compounds with novel structure and outstanding activity have been identified. Iridoid compounds have been confirmed to mainly exist as the prototype and aglycone and Ι and II metabolites, by biological transformation. These metabolites have been shown to have neuroprotective, hepatoprotective, anti-inflammatory, antitumor, hypoglycemic, and hypolipidemic activities. This review summarizes the new structures and activities of iridoids identified locally and globally, and explains their pharmacokinetics from the aspects of absorption, distribution, metabolism, and excretion according to the differences in their structures, thus providing a theoretical basis for further rational development and utilization of iridoids and their metabolites. View Full-Text
Keywords: iridoids; phytochemistry; biological activities; pharmacokinetics iridoids; phytochemistry; biological activities; pharmacokinetics
Show Figures

Figure 1

MDPI and ACS Style

Wang, C.; Gong, X.; Bo, A.; Zhang, L.; Zhang, M.; Zang, E.; Zhang, C.; Li, M. Iridoids: Research Advances in Their Phytochemistry, Biological Activities, and Pharmacokinetics. Molecules 2020, 25, 287.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop