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Special Issue "Curcumin"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 30 June 2019

Special Issue Editors

Guest Editor
Dr. Erika Ferrari

Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, via Campi, 103-41125 Modena, Italy
Website | E-Mail
Interests: curcumin; metal-based drugs; PET-radiotracers; gallium-68; curcuminoids; NMR spectroscopy
Co-Guest Editor
Dr. Carol Imbriano

Department of Life Sciences, University of Modena and Reggio Emilia, via Campi, 113/d-41125 Modena, Italy
Website | E-Mail
Interests: gene transcription; cancer biology; cell proliferation and differentiation; splicing; curcuminoids

Special Issue Information

Dear Colleagues,

Curcumin, commonly classified as a natural occurring polyphenol, is the primary bioactive compound isolated from the dried rhizomes of Curcuma longa L. In the past decades, a large number of reports have been published on the beneficial effects of curcumin, and it has repeatedly been claimed that this natural active principle, which is considered safe, could be the lead compound for the development of new therapeutics. The molecular structure of curcumin (CUR) accounts for its pleiotropic set of biological properties, including anti-oxidant, anti-inflammatory, anti-tumor and neuroprotective activity. Many efforts have been devoted to the development of new derivatives, formulations and to understand the molecular mechanisms both in vitro and in vivo. This Special Issue aims to collect the actual knowledge and new trends in all areas dealing with curcumin.

Topics of interest will include, but are not limited to:

  • Design and development of new derivatives
  • Innovative formulations
  • Metabolism
  • Cancer therapy
  • Neurological disorders

You are cordially invited to contribute to this Special Issue on “Curcumin” with original articles, reviews and short communications.

Dr. Erika Ferrari
Dr. Carol Imbriano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Curcumin
  • Curcumin analogs
  • Pharmaceutical formulations
  • Molecular mechanisms
  • Cancer
  • Anti-oxidant activity
  • Docking and modeling

Published Papers (2 papers)

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Research

Open AccessArticle
Curcumin and Resveratrol Regulate Intestinal Bacteria and Alleviate Intestinal Inflammation in Weaned Piglets
Molecules 2019, 24(7), 1220; https://doi.org/10.3390/molecules24071220
Received: 2 March 2019 / Revised: 23 March 2019 / Accepted: 27 March 2019 / Published: 28 March 2019
PDF Full-text (1494 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Human infants or piglets are vulnerable to intestinal microbe-caused disorders and inflammation due to their rapidly changing gut microbiota and immaturity of their immune systems at weaning. Resveratrol and curcumin have significant anti-inflammatory, bacteria-regulating and immune-promoting effects. The purpose of this study was [...] Read more.
Human infants or piglets are vulnerable to intestinal microbe-caused disorders and inflammation due to their rapidly changing gut microbiota and immaturity of their immune systems at weaning. Resveratrol and curcumin have significant anti-inflammatory, bacteria-regulating and immune-promoting effects. The purpose of this study was to investigate whether dietary supplementation with resveratrol and curcumin can change the intestinal microbiota and alleviate intestinal inflammation induced by weaning in piglets. One hundred eighty piglets weaned at 21 ± 2 d were fed a control diet (CON group) or supplemented diet (300 mg/kg of antibiotics, ANT group; 300 mg/kg of resveratrol and curcumin, respectively, HRC group; 100 mg/kg of resveratrol and curcumin, respectively, LRC group; 300 mg/kg of resveratrol, RES group; 300 mg/kg of curcumin, CUR group) for 28 days. The results showed that compared with the CON group, curcumin alone and antibiotics decreased the copy numbers of Escherichia coli. Both curcumin and resveratrol down-regulated the level of Toll-like-receptor 4 mRNA and protein expression in the intestine to inhibit the release of critical inflammation molecules (interleukin-1β, tumor necrosis factor-α), and increase the secretion of immunoglobulin. Our results suggested that curcumin and resveratrol can regulate weaned piglet gut microbiota, down-regulate the TLR4 signaling pathway, alleviate intestinal inflammation, and ultimately increase intestinal immune function. Full article
(This article belongs to the Special Issue Curcumin)
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Open AccessArticle
Liposomal Curcumin is Better than Curcumin to Alleviate Complications in Experimental Diabetic Mellitus
Molecules 2019, 24(5), 846; https://doi.org/10.3390/molecules24050846
Received: 29 January 2019 / Revised: 19 February 2019 / Accepted: 26 February 2019 / Published: 27 February 2019
Cited by 2 | PDF Full-text (1100 KB) | HTML Full-text | XML Full-text
Abstract
Curcumin (CC) is known to have anti-inflammatory and anti-oxidative properties and has already been tested for its efficiency in different diseases including diabetes mellitus (DM). New formulations and route administration were designed to obtain products with higher bioavailability. Our study aimed to test [...] Read more.
Curcumin (CC) is known to have anti-inflammatory and anti-oxidative properties and has already been tested for its efficiency in different diseases including diabetes mellitus (DM). New formulations and route administration were designed to obtain products with higher bioavailability. Our study aimed to test the effect of intraperitoneal (i.p.) administration of liposomal curcumin (lCC) as pre-treatment in streptozotocin(STZ)-induced DM in rats on oxidative stress, liver, and pancreatic functional parameters. Forty-two Wistar-Bratislava rats were randomly divided into six groups (seven animals/group): control (no diabetes), control-STZ (STZ-induced DM —60 mg/100g body weight a single dose intraperitoneal administration, and no CC pre-treatment), two groups with DM and CC pre-treatment (1mg/100g bw—STZ + CC1, 2 mg/100g bw—STZ + CC2), and two groups with DM and lCC pre-treatment (1 mg/100g bw—STZ + lCC1, 2 mg/100g bw—STZ + lCC1). Intraperitoneal administration of Curcumin in diabetic rats showed a significant reduction of nitric oxide, malondialdehyde, total oxidative stress, and catalase for both evaluated formulations (CC and lCC) compared to control group (p < 0.005), with higher efficacy of lCC formulation compared to CC solution (p < 0.002, excepting catalase for STZ + CC2vs. STZ + lCC1when p = 0.0845). The CC and lCC showed hepatoprotective and hypoglycemic effects, a decrease in oxidative stress and improvement in anti-oxidative capacity status against STZ-induced DM in rats (p < 0.002). The lCC also proved better efficacy on MMP-2, and -9 plasma levels as compared to CC (p < 0.003, excepting STZ + CC2 vs. STZ + lCC1 comparison with p = 0.0553). The lCC demonstrated significantly better efficacy as compared to curcumin solution on all serum levels of the investigated markers, sustaining its possible use as adjuvant therapy in DM. Full article
(This article belongs to the Special Issue Curcumin)
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