Targeting Innovation in Medicinal Chemistry

Dear Colleagues,

Medicinal chemistry research has been experiencing a golden age in terms of innovative approaches to both target identification and validation, key steps in the finding of new chemical entities (NCEs). Undoubtedly, the advancement of fundamental knowledge has been greatly accelerated by the development of new theoretical and experimental methods along with technological progresses, which have enabled the consolidation of valuable computational routines such as virtual screening, as well as eco-sustainable options to access drugs in scalable and safe ways such as flow-chemistry. Accordingly, this Special Issue, dedicated to Prof. Ettore Novellino on the occasion of his retirement, will address innovation in any field of interest for medicinal chemists, including but not limited to anticancer, antiviral, and antimicrobial agents, as well as therapeutics for neurodegenerative diseases and inflammation. Targets like proteins and canonical and noncanonical nucleic acid structures will be relevant to the scope of the Issue. More specifically, original research articles focused on the design, synthesis, and biological evaluation of small molecules, peptides, and oligomers, as well as the investigation of bioactive molecules able to complement pharmacological therapy, such as nutraceuticals, are welcome. Likewise, review articles highlighting state-of-the-art in the field will be appreciated.

Prof. Dr. Jussara Amato
Dr. Mariateresa Giustiniano
Guest Editors

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