Recent Advances in the Discovery of Biologically Relevant Small Molecules
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 4321
Special Issue Editors
Interests: medicinal chemistry; drug discovery; chirality
* Associate Professor
Special Issues, Collections and Topics in MDPI journals
Interests: biologically active compounds; chirality; antimyotonic agents; antiarrhythmics; antimicrobials; anticancers; α-glucosidase inhibitors; synthesis and extraction of antioxidant agents
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Small molecules are low-molecular-weight compounds that, due to their small size, easily cross cell membranes to reach a wide range of intracellular targets. This is why they play a pivotal role in most of the challenges facing human health, such as cancer, cardiovascular diseases, metabolic diseases, and infectious diseases, to mention just a few. Unfortunately, small molecules are often biased by off-target activities responsible for undesired side effects and toxicity. Therefore, many efforts are continuously devoted to the identification of novel viable and safe drug candidates to fulfill more effective therapies for human diseases. The current Special Issue aims to collect original research articles as well as reviews on recent advances in the identification of synthetic, semi-synthetic, or naturally occurring small molecules as potential drug candidates in different therapeutic areas.
Potential topics include (but are not limited to) the following:
- Drug discovery;
- Synthesis of pharmaceutically relevant compounds;
- Isolation and identification of biologically active natural products;
- In vitro, ex vivo, and in vivo biological evaluation;
- Molecular docking;
- Drug repositioning.
Dr. Giovanni Lentini
Dr. Maria Maddalena Cavalluzzi
Dr. Gualtiero Milani
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- drug discovery
- small molecules
- natural compounds
- biological evaluation
- molecular docking
- drug repositioning
