Cannabinoids in Cannabis: Chemistry, Pharmacology and Real World Evidence

Dear Colleagues,

Cannabinoids, viz. endocannabinoids and phytocannabinoids, play an important role in a number of diseases spanning immunological, neurological and neuroimmunological conditions. These compounds interestingly act as ligands to a number of receptors and ion channels, such as CB1, CB2, GPR55, 5HT_1A, and TRPV channels, among others. In recent years, there has been a renewed interest in almost all aspects of cannabinoids and the endocannabinoid system (ECS) due to the relaxation of regulations around the globe. This is permitting us to answer many questions that could not be answered until now, in the context of chemical modifications to cannabinoids, effects of cannabinoids on receptors, pharmacology and physiology, and associated clinical evidence. Chemical modifications to endocannabinoids and phytocannabinoids are important to probe the in vitro and in vivo pharmacology. Cannabinoids, in the form of various cannabis-derived products, are available in many countries, and research on these products and their effects on receptors—in animal models and in humans—are also very much relevant to health.

This Special Issue aims to bring together high-quality publications that appreciate and investigate the diversity of cannabinoid chemistry, the chemical complexity of cannabis, in vitro and in vivo studies involving cannabinoids and/or cannabis products, and real-world evidence on chemically defined cannabis products.

 

Prof. Lakshmi P. Kotra
Guest Editor

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