Design and Synthesis of Biologically Active Peptides
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 7226
Special Issue Editor
Interests: chemical peptide synthesis; solid-phase peptide synthesis; antimicrobial peptides; lanthipeptides; lantibiotics; unusual amino acids; peptidomimetics; antimicrobial resistance; greener chemical peptide synthesis
Special Issue Information
Naturally occurring biologically active peptides, and their derivatives, continue to be a source of potential therapeutics, with the number of such compounds being developed continuing to rise. Using these as a starting point or template, the number of research groups and companies involved in the design and synthesis of biologically active peptides, and their many derivatives, is also growing significantly. By their nature, peptides reside on the spectrum between the small molecules and the larger proteins/biologics. Peptides are usually amenable to chemical synthesis like small molecules, as well as retaining the exquisite selectivity of larger proteins. The introduction of solid-phase peptide synthesis by Bruce Merrifield in the 1960s revolutionized the chemical synthesis of peptides, which, along with newer ligation technologies, has meant that the synthesis of complex peptides has now become more “routine”, on par with small molecules.
In parallel, significant advances in spectroscopic, spectrometric, and computational capability, from both a hardware and software perspective, has allowed the de novo design of novel peptide entities, with a range of built-in, specifically targeted properties, to become mainstream. The study of peptide–protein interactions, both computationally and spectroscopically, has also progressed at a rapid pace, where new therapies, and other applications, will be developed in the coming years.
The main aim of this Special Issue is to highlight the wealth of research taking place throughout the world in the “peptide design and synthesis” arena. Contributions to this issue, in the form of original research papers, or review articles, in the area of the design of novel peptides, to computational studies, to their chemical synthesis or semi-synthesis, along with the associated methodology development, will be very welcome.
Dr. Fintan Kelleher
Guest Editor
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Keywords
- de novo design of biologically active peptides and derivatives
- SPPS of biologically active peptides and derivatives
- antimicrobial peptide design and synthesis
- anticancer peptides and metallopeptides
- computational studies leading to the synthesis of conformationally constrained bioactive peptides
- spectrometric and spectroscopic studies of bioactive peptides
- peptides with non-standard amino acid residues
- design and synthesis of stapled peptides
- cyclic and macrocyclic peptides, including analogues
- new synthetic methodologies toward bioactive peptides
- design and synthesis of peptidomimetics
- design and synthesis of cell penetrating peptides
- Synthesis of glycopeptides and peptide nucleic acid (PNAs)
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