Discovery of Anti-Inflammatory Compounds

Dear Colleagues,

Inflammation, characterised by the four key cardinal features of inflammation are pain, redness, warmth and swelling, was one of the earliest recognised and defined disease entities. The pioneer drug acetylsalicylic acid, isolated from the willow bark (Salix) in the 1880s, received fame as being the gold standard in treating inflammatory conditions. However, the therapeutic effects were later overshadowed by its adverse gastrointestinal effects which prevented its long-term use as an anti-inflammatory agent. Since then there has been a continuously growing interest in the discovery of molecules that would surpass the anti-inflammatory properties of acetylsalicylic acid, with a focus on minimum adverse effects on the human body. Plants have long been a promising source of anti-inflammatory molecules, showcased by a remarkable breadth of structural scaffolds and chemical diversity exhibiting potential for the discovery of a new generation of anti-inflammatory molecules. In addition, the mechanism of action of anti-inflammatory molecules has been of a growing interest and may lead to the possibility of a renewed interest in old plant natural products. This Special Issue plans on capturing research papers that have a focus on reporting the discovery of new/novel plant natural products and/or the discovery of the molecular targets of new/novel anti-inflammatory agents.

Dr. Ritesh Raju
Guest Editor

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