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NUCLEO-OMICS24
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NUCLEO-OMICS24

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 938

Special Issue Editors

Dr. Giovanni N. Roviello

E-Mail Website
Guest Editor
Institute of Biostructures and Bioimaging, Italian National Council for Research (IBB-CNR), Via P. Castellino 111, 80131 Naples, Italy
Interests: bioinorganic chemistry; synthetic chemistry; nucleic acid chemistry; spectroscopic studies; computational studies; environmental chemistry
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Valentina Mittova

E-Mail Website
Guest Editor
Scientific-Research Institute of Experimental and Clinical Medicine, Teaching University Geomedi, LLC, 4 King Solomon II Street, Tbilisi 0114, Georgia
Interests: plants; antioxidants; flavonoids; ascorbate; glutathione; ascorbate-glutathione cycle; antibacterial activity; catalase; peroxidase; glutathione reductase

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit to the Special Issue of Molecules dedicated to the NUCLEO-OMICS24 international workshop, which will take place in Naples, Italy, on October 30-31, 2024, at the Aula Magna of Scienze Biotecnologiche Building.

Notably, Molecules is also represented at the event:

https://www.mdpi.com/journal/molecules/events/17846

The event will focus on the latest advancements in research on organic molecules, biomacromolecules, and their applications in chemistry, biotechnology, and systems biology.

The meeting will address cutting-edge topics, including:

  • Dynamics of biomacromolecule-ligand interactions;
  • Photoactivatable polymeric nanoconstructs for unconventional therapies;
  • NMR-based metabolomics for bioactive natural products;
  • Supramolecular architectures and multivalent tools in biomedical applications.

The second day will emphasize the interaction between Mediterranean natural substances and organic biomacromolecules, exploring their potential in medicinal chemistry and precision medicine.

This Special Issue is open to the workshop participants and all researchers working in the above fields. We welcome original research articles, reviews, and communications related to the themes discussed during the workshop.

Submission Information: Manuscripts can be submitted online through the Molecules MDPI portal. All submissions will be peer-reviewed, and accepted papers will be published on an open access basis. Please visit the Molecules website for more information on submission guidelines and fees.

We look forward to receiving your contributions and hope to foster new collaborations within the scientific community.

Dr. Giovanni N. Roviello
Prof. Dr. Valentina Mittova
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dynamics of biomacromolecule-ligand interactions
  • photoactivatable polymeric nanoconstructs for unconventional therapies
  • NMR-based metabolomics for bioactive natural products
  • supramolecular architectures and multivalent tools in biomedical applications

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

14 pages, 2275 KiB  
Article
The Ligand Binding Domain of the Cell Wall Protein SraP Modulates Macrophage Apoptosis and Inflammatory Responses in Staphylococcus aureus Infections
by He Sun, Robert W. Li, Thomas T. Y. Wang and Lin Ding
Molecules 2025, 30(5), 1168; https://doi.org/10.3390/molecules30051168 - 5 Mar 2025
Viewed by 541
Abstract
The Staphylococcus aureus cell wall protein serine rich adhesin for platelets (SraP) belongs to a large surface glycoprotein family of adhesins. Here, we provide experimental evidence that SraP mediates macrophage functions in a human monocyte-derived macrophage model via its N-terminal L-lectin module (LLM) [...] Read more.
The Staphylococcus aureus cell wall protein serine rich adhesin for platelets (SraP) belongs to a large surface glycoprotein family of adhesins. Here, we provide experimental evidence that SraP mediates macrophage functions in a human monocyte-derived macrophage model via its N-terminal L-lectin module (LLM) in the ligand binding region. Our flow cytometry data demonstrated that macrophages infected by the LLM deletion strain profoundly impacted apoptosis, reducing the percentage of apoptotic cells by approximately 50%, whereas LLM overexpression significantly increased the percentage of early-stage apoptotic cells (p < 0.001). LLM deletion significantly enhanced phagocytosis by macrophages by increasing the number of engulfed bacteria, resulting in a significant increase in bacterial killing and leading to a notable decrease in bacterial survival within macrophages (p < 0.001). Furthermore, LLM modulated the ability of S. aureus to elicit inflammatory responses. The LLM deletion strain dampened the expression of proinflammatory factors but increased the expression of anti-inflammatory cytokines, such as IL10. Our evidence suggests that SraP likely plays a dual role in S. aureus pathogenesis, by acting as a virulence factor involved in bacterial adhesion and invasion and by mediating macrophage functions. Our future work will focus on the identification of small molecule inhibitors of LLM using molecular docking-based in silico screening and in vivo validation. Developing LLM inhibitors, alone or in combination with conventional antibiotics, may represent a novel strategy for combating S. aureus infections. Full article
(This article belongs to the Special Issue NUCLEO-OMICS24)
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