The Role of TLR4 Signalling in Haematological Diseases

Dear Colleagues,

Toll-like receptors (TLRs) belong to the pattern recognition receptors, and their activation generates inflammatory responses as part of the innate immune system. These receptors have a role in the regulation of normal biological functions, and in carcinogenesis/leukaemogenesis. TLR4 is considered to be among the immunotherapeutic targets with a high potential to cure cancer. It is expressed by normal haematopoietic cells, and signalling through TLR4 leads to stem cell differentiation during normal and possibly also leukemic haematopoiesis. In acute myeloid leukaemia, for instance, TLRs are expressed by the leukemic blasts and have gained interest as potential drug targets for AML therapy in order to eradicate residual leukemic cells after induction therapy.

In this Special Issue, we intend to focus on the potentials of targeting the TLR4 signalling pathway, both upstream and downstream of the receptor, with natural or synthetic compounds. The scope includes haematological diseases such as leukaemias and lymphomas, as well as pre-leukemic syndromes (myelodysplastic syndromes) or normal changes during aging. We welcome scientific articles, reviews and communications.

Dr. Annette K. Brenner
Prof. Dr. Øystein Bruserud
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.