Solid-State of Organic Pharmaceutical Compounds
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Materials Chemistry".
Deadline for manuscript submissions: closed (15 April 2022) | Viewed by 25963
Special Issue Editor
Interests: molecular dynamics; nucleation; polymorphism; active pharmaceutical ingredients; crystallization; calorimetry; instrumentation; ionic liquids
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The crystal phase plays a crucial role in the properties of active pharmaceutical ingredients (API), since different solid forms of the same compound often exhibit different physical properties (e.g., fusion temperature, solubility, stability, crystal morphology, and dissolution rate). The ability to control the solid phase of materials was, therefore, recognized as an effective method to tune the properties of APIs, attracting attention in the scientific community in recent decades. The current Special Issue aims to provide a view of the most recent advances in solid-state studies. The topics of interest include the study of polymorphism, solvates, and co-crystals; the investigation of the nucleation and growth of crystals from solution; the crystallization of materials with well-defined size and morphology; chiral separation; solubility studies; and the development of theoretical approaches for the predictions of properties of crystallized materials (e.g., crystal phase and solubility).
Dr. Carlos Eduardo Sabino Bernardes
Guest Editor
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Keywords
- Crystallization
- Polymorphism
- Nucleation
- Solvatomorphism
- Co-crystallization
- Solubility
- Solid phase stability
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