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Special Issue "Organometallic Compounds: Synthesis and Biological Activity"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organometallic Chemistry".

Deadline for manuscript submissions: 28 February 2021.

Special Issue Editors

Prof. Dr. Evamarie Hey-Hawkins
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Guest Editor
Institute of Inorganic Chemistry, Leipzig University, Johannisallee 29, D-04103 Leipzig, Germany
Interests: inorganic chemistry; (chiral, functionalised) phosphorus compounds; carboranes; homogeneous catalysis with mono- and multinuclear transition metal complexes; biological and medicinal chemistry with inorganic compounds
Special Issues and Collections in MDPI journals
Prof. Dr. Santiago Gómez-Ruiz
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Guest Editor
Department of Biology, Geology, Physics and Inorganic Chemistry, Universidad Rey Juan Carlos, Mostoles, Spain
Interests: nanomaterials; catalysis; photocatalysis; anticancer; metallodrugs
Special Issues and Collections in MDPI journals
Prof. Dr. Goran Kaluđerović
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Guest Editor
Department of Engineering and Natural Sciences, University of Applied Sciences Merseburg, Eberhard-Leibnitz-Strasse 2, 06217 Merseburg, Germany
Interests: inorganic nanoparticles; cancer treatment; cancer diagnostics; drug delivery systems; cancer targeting
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Organometallic compounds are important as homogeneous catalysts for the production of pharmaceuticals, among many other products. However, since the reports of the first organometallic chemotherapeutic agent, salvarsan, by Paul Ehrlich (1854–1915, Nobel Prize in Physiology or Medicine in 1908), it has been realized that they can also play an important role as biologically active compounds in the design of novel pharmaceuticals. While only a few organometallic complexes that contain at least one direct metal-carbon bond occur in nature, such as vitamin B12 and some iron and nickel hydrogenases, many organometallic complexes have been studied for biological and medicinal applications. This Special Issue will collect the most recent contributions on the synthesis and biological activities of organometallic complexes in the treatment of viral, fungal, bacterial, and parasitic infections, as well as in the diagnosis and treatment of cancer (also as theranostics), as NO- or CO-releasing molecules, radiopharmaceuticals or for bioanalytical applications.

Prof. Dr. Evamarie Hey-Hawkins
Prof. Dr. Santiago Gómez-Ruiz
Prof. Dr. Goran Kaluđerović
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Antitumour agents
  • Antimicrobial agents 
  • CO-releasing molecules
  • NO-releasing molecules
  • Radiopharmaceuticals
  • Bioanalytics
  • Theranostics

Published Papers (1 paper)

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Review

Open AccessReview
Recent Advances in the Reactions of Cyclic Carbynes
Molecules 2020, 25(21), 5050; https://doi.org/10.3390/molecules25215050 - 30 Oct 2020
Abstract
The acyclic organic alkynes and carbyne bonds exhibit linear shapes. Metallabenzynes and metallapentalynes are six- or five-membered metallacycles containing carbynes, whose carbine-carbon bond angles are less than 180°. Such distortion results in considerable ring strain, resulting in the unprecedented reactivity compared with acyclic [...] Read more.
The acyclic organic alkynes and carbyne bonds exhibit linear shapes. Metallabenzynes and metallapentalynes are six- or five-membered metallacycles containing carbynes, whose carbine-carbon bond angles are less than 180°. Such distortion results in considerable ring strain, resulting in the unprecedented reactivity compared with acyclic carbynes. Meanwhile, the aromaticity of these metallacycles would stabilize the ring system. The fascinating combination of ring strain and aromaticity would lead to interesting reactivities. This mini review summarized recent findings on the reactivity of the metal–carbon triple bonds and the aromatic ring system. In the case of metallabenzynes, aromaticity would prevail over ring strain. The reactions are similar to those of organic aromatics, especially in electrophilic reactions. Meanwhile, fragmentation of metallacarbynes might be observed via migratory insertion if the aromaticity of metallacarbynes is strongly affected. In the case of metallapentalynes, the extremely small bond angle would result in high reactivity of the carbyne moiety, which would undergo typical reactions for organic alkynes, including interaction with coinage metal complexes, electrophilic reactions, nucleophilic reactions and cycloaddition reactions, whereas the strong aromaticity ensured the integrity of the bicyclic framework of metallapentalynes throughout all reported reaction conditions. Full article
(This article belongs to the Special Issue Organometallic Compounds: Synthesis and Biological Activity)
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