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Special Issue "Forensic Practices and Innovations: Instrumental Analyses, Data Correlations, Legislative Comments, and Case Studies"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: 31 July 2021.

Special Issue Editors

Prof. Dr. Marcello Locatelli
SciProfiles
Guest Editor
Department of Pharmacy, University of G. d'Annunzio Chieti and Pescara, Chieti, Italy
Interests: innovative (micro) extraction procedures (MEPS, FPSE, DLLME, SULLE, MAE, etc.) and hyphenated instrument configurations; bioactive compounds (drugs, drugs associations, and natural bioactive compounds); characterization, fingerprints, and method validation; HPLC; mass spectrometry (MS and MS/MS)
Special Issues and Collections in MDPI journals
Dr. Angela Tartaglia
Website
Guest Editor
University "G. d'Annunzio" of Chieti-Pescara; Dept. of Pharmacy, Via dei Vestini 31 - 66100 Chieti, Italy
Interests: method development; analytical and bioanalytical chemistry; method validation; hyphenated assay; HPLC
Special Issues and Collections in MDPI journals
Prof. Dr. Abuzar Kabir
Website
Guest Editor
International Forensic Research Institute, Department of Chemistry and Biochemistry, Florida International University, Miami, Florida, USA
Interests: chromatographic stationary phases; substrate-free solid-phase extraction sorbents; molecular imprinting technology; sorbents for environmental pollution remediation; miniaturized sample preparation devices; field deployable sample preparation technology
Special Issues and Collections in MDPI journals
Dr. Cristian D’Ovidio
Website
Guest Editor
Department of Medicine and Aging Sciences, Section of Legal Medicine, University of Chieti–Pescara “G. d’Annunzio”, Via dei Vestini, 31; I-66100 Chieti; Italy
Interests: medical professional liability; forensic dentistry; forensic pathology (in particular sudden deaths) and autoptic technique; histopathological and immunohistochemical sciences; forensic genetics; forensic toxicology; forensic pharmacology and applied analytical chemistry; study of inflammatory processes
Dr. Ugo De Grazia
Website SciProfiles
Guest Editor
IRCCS Neurological Institute Foundation Carlo Besta, Laboratory of Neurological Biochemistry and Neuropharmacology, Via Celoria 11, I-20133 Milan, Italy
Interests: antiepileptics and benzodiazepines; pharmacokinetics and toxicology; microsampling; saliva and liquor matrices; cannabinoids and TDM
Dr. Fabio Savini
Website
Guest Editor
Pharmatoxicology Laboratory—Hospital “Santo Spirito”, Via Fonte Romana 8, I-65124 Pescara, Italy
Interests: dosages of drugs, toxicological and alcohol screening also on alternative matrices (hair, hair, saliva, sweat and various), with tests carried out on high performance analytical systems, and of the latest generation; confirmatory analysis with chromatographic systems LC-MS/MS, GC-MS and HPLC for drugs, acute and chronic abuse of alcohol, biogenic amines, drugs, occupational toxicology and various analytes
Dr. Roberta Risoluti

Guest Editor
"Sapienza" University of Rome, Dept. of Chemistry, p.le Aldo Moro 5 - 00185 Rome, Italy
Interests: chemometrics; forensic analysis; microNIR spectroscopy; thermal analysis; clinical and biomedical applications
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

There are serious concerns about the widespread use of new drugs (NPS—New Psychoactive Substances) and the consumption of illicit substances that, although currently stable, shows high percentages due to the increases recorded in the late 1990s. NPS play an increasingly important role in this area, as they are often difficult to detect with the conventional screening procedures currently available to police. This implies a negative result in screening tests even if the subject has made use of illicit substances. This field also includes routine analyses regarding the presence of alcohol and/or other drugs often found during normal checks and during autopsies, as well as the possibility of correlating the concentrations of the same analyte in matrices other than those of choice for medicolegal purposes.

Today, we are witnessing an incredible increase in interest in the field of Forensic Sciences, the possible applications of new instrumental configurations techniques and sample treatment, statistical/chemometric approaches, legal implications, analysis on unconventional samples, and a possible correlation between analyte concentrations detected in different matrices.

This Special Issue aims to collect the state-of-the-art on the main topics in the Forensic field: hyphenated techniques and instrument configurations, innovative sample treatment procedures, forensic analysis, legislative comments, nonconventional matrix analysis, new psychoactive substances, chemometric approaches, and social situations. The aim is to produce a collection/commentary that can make even non-experts understand the application potential of the innovations obtained in this area and, if necessary, apply and extend them to other fields. In order not to limit the types of publications and to provide a more detailed panorama of the topic, original papers, reviews, short communications, notes, commentaries, case studies and application notes will be accepted. In particular, “case studies” can be a sort of short communication where the authors directly report a practical case where, perhaps, they have applied innovative approaches to solve the problem. “Legislative comments” refer to a series of articles where laboratory experts comment on the problems encountered in reconciling what the law requires with what can be done in the laboratory, as well as suggesting possible meeting points.

This Special Issue is supported by the Sample Preparation Task Force and Network, of the European Chemical Society-Division of Analytical Chemistry (https://www.sampleprep.tuc.gr/en/home/).

Dr. Abuzar Kabir
Prof. Dr. Marcello Locatelli
Dr. Roberta Risoluti
Dr. Angela Tartaglia
Dr. Cristian D’Ovidio
Dr. Ugo De Grazia
Dr. Fabio Savini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Hyphenated techniques and instrument configurations
  • Innovative sample treatment procedures
  • Forensic analyses
  • Legislative comments
  • Nonconventional matrix analysis
  • New psychoactive substances
  • Chemometric approaches
  • Social situation.

Published Papers (1 paper)

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Research

Open AccessFeature PaperArticle
Ethanol Determination in Post-Mortem Samples: Correlation between Blood and Vitreous Humor Concentration
Molecules 2020, 25(12), 2724; https://doi.org/10.3390/molecules25122724 - 12 Jun 2020
Abstract
Ethanol (ethylic alcohol) represents the most commonly used drug worldwide and is often involved in clinical and forensic toxicology. Based on several reports, excessive alcohol consumption is the main contributing factor in traffic accidents, drownings, suicides, and other crimes. For these reasons, it [...] Read more.
Ethanol (ethylic alcohol) represents the most commonly used drug worldwide and is often involved in clinical and forensic toxicology. Based on several reports, excessive alcohol consumption is the main contributing factor in traffic accidents, drownings, suicides, and other crimes. For these reasons, it becomes essential to analyze the alcohol concentration during autopsy. Although blood is usually used for alcohol analysis in post-mortem cases, it could suffer alterations, putrefaction, and microbial contaminations. As an alternative to whole blood, vitreous humor has been successfully used in medico-legal studies. In this work, post-mortem specimens were analyzed for ethanol determination. The analysis of blood and vitreous humor were carried-out using gas chromatography-flame ionized detector (GC-FID) with a total run time of 6 min. The method was validated in terms of limit of detection, limit of quantification, dynamic range, sensibility, recovery, precision and trueness. A linear regression analysis indicated a coefficient of determination (R2) of 0.9981. The study confirmed no statistically differences between alcohol concentration in blood and vitreous humor, leading vitreous humor as an excellent matrix that could be used as an alternative to whole blood in toxicological analysis in cases where blood is not available. Full article
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