Discovery and Development of Antidiabetic Agents from Natural Products

Dear Colleagues,

Type 2 diabetes mellitus (T2DM) is a multifactorial chronic disease, characterized by a prolonged increase in blood glucose levels, which causes macrovascular and microvascular complications. T2DM is characterized by beta-cell dysfunction, insulin resistance, and chronic inflammation, which also cause accelerated age-related damage. To explain how hyperglycemia can induce diabetic complications, a key mechanism is the accumulation of non-enzymatic glycosylation (or glycation) products of proteins and lipids, with the formation of advanced glycation end products (AGEs). These are triggered by endogenous processes related to hyperglycemia and oxidative stress. In relation to these observations, the recognition of natural products, isolated compounds, or new synthetic compounds capable to reduce glycaemia and AGEs formation represents a great challenge in medicine. 

Prof. Dr. Guglielmina Froldi
Guest Editor

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