Dopamine Receptors and Neurodegeneration

Dear Colleagues,

Dopaminergic dysfunctions can contribute to diverse neuropsychiatric and neurodegenerative disorders, characterized by progressive neuronal loss that leads to degeneration at different levels of the nervous system. Disrupted dopamine (DA) homeostasis, and more specifically dopamine receptor alterations, have been reported in a variety of psychiatric and neurodegenerative disorders.

The present Special Issue provides an excellent opportunity to converge the most updated state of current research studies related to the implication of DA receptors in a variety of neurodegenerative disorders due to the unclear pathogenesis underlying neurodegeneration.

We call for genetic studies as well as basic behavioral and pharmaceutical approaches to help understand better the critical role of each DA receptor in psychopathology to allow the discovery of new treatment approaches for such devastating impacts of neurodegenerative diseases worldwide.

Potential topics include, but are not limited to, the following:

• Dopamine receptor mechanisms of action on neurodegeneration;
• The behavioral impacts of DA receptor alterations;
• Adverse effects of the DA system on neurodegenerative diseases;
• Molecular basis of DA impairments and their impact on neurodegeneration;
• Future perspectives for neurodegeneration interventions: dopamine implications;
• Genetical approaches: implications of DA in neurodegeneration.

Dr. Marta Pardo
Guest Editor

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