Novel Insights toward the Development of New Drugs
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 4770
Special Issue Editors
Interests: drug design; small molecules; natural compounds; protein targeting; anticancer; antiviral; metabolic disorders
Special Issues, Collections and Topics in MDPI journals
Interests: drug stability; photodegradation; light-stable formulations
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The drug development process is notoriously long and intricate, as several aspects need to be considered to ensure the chemical and pharmaceutical quality, safety profile, and efficacy of therapeutic candidates. However, computer-aided drug design has advanced tremendously, providing numerous advantages in terms of cost and time. In addition, several relatively low-risk strategies for the repositioning of existing drugs for new therapeutic indications are under investigation.
In the advanced stages of drug development, stability studies represent a key step for the approval of new active ingredients or pharmaceutical formulations. These studies ensure that the product or active substance satisfies the specified storage conditions for the entire shelf life. In this context, the ICH Q1A-Q1F guidelines serve as a reference. The selection of the appropriate parameters, as well as a precise and correct project strategy, are required for relevant and reliable data.
This Special Issue aims to highlight the current efforts in medicinal chemistry and pharmacology towards the development of novel drugs or pharmaceutical formulations. Its content will focus on advanced drug discovery approaches by in silico identification of alternative natural and synthetic therapeutic agents, structure-activity relationships definition and the design of convenient pathways for the preparation and the stability evaluation of novel or reproposed effective agents. Nanotechnologies application and biological evaluation of newly synthesized or known drugs will also be considered.
Dr. Fedora Grande
Dr. Giuseppina Ioele
Guest Editors
Manuscript Submission Information
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Keywords
- natural and synthetic compounds
- drug design and synthesis
- molecular docking and dynamic simulations
- structure-activity relationships
- target validation
- biological evaluation
- drug stability
- protective systems
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