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Synthesis of Natural or Non-natural Molecules with Specific Activities

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 765

Special Issue Editor


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Guest Editor
Institut de Chimie Organique et Analytique (ICOA), Université d’Orléans, UMR-CNRS 7311, BP 6759, Rue de Chartres, 45067 Orléans, France
Interests: organic synthesis; hemi-synthesis; green chemistry; sustainable solvents and processes; therapeutic molecules
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The aim of this Special Issue is to highlight work on the synthesis of natural or non-natural molecules with specific therapeutic, agrochemical or cosmetic activities. It is important to list the latest advances in terms of synthetic routes or scaling-up processes to obtain bioactive molecules known for various activities or of potential interest following in vitro tests. Any research reporting improvements in pathways that may involve milder conditions than those used previously, atom economy, and faster syntheses is of interest for this Special Issue.

Work reporting improvements in the hemi-synthesis of natural molecules or relevant pharmacomodulations of natural or non-natural molecules is also welcome. All types of molecules of biological interest are covered by this Special Issue, whether they are heterocycles, glycosides or nucleosides.

Prof. Dr. Sabine Berteina-Raboin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactives molecules
  • therapeutic or agrochemical activities
  • hemisynthesis
  • optimized access pathway
  • optimized scale up
  • green chemistry

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Published Papers (1 paper)

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Review

21 pages, 4810 KiB  
Review
Flavonoids and Furanocoumarins Involved in Drug Interactions
by Sabine Berteina-Raboin
Molecules 2025, 30(8), 1676; https://doi.org/10.3390/molecules30081676 - 9 Apr 2025
Viewed by 391
Abstract
Drug interactions can have significant consequences for public health, especially given the growing importance of readily available dietary supplements. The same applies to the consumption of fruit and fruit juices, which are often praised for their health benefits, but which can generate drug [...] Read more.
Drug interactions can have significant consequences for public health, especially given the growing importance of readily available dietary supplements. The same applies to the consumption of fruit and fruit juices, which are often praised for their health benefits, but which can generate drug interactions. These are well known and documented in the case of grapefruit, which should not be taken with certain medications. Grapefruit contains flavonoids and furanocoumarins, which are responsible for various interactions with the cytochrome P450 enzyme system. However, for young children and the elderly, fruit juices are often used to facilitate treatment. This review examines commonly used fruit juices, particularly from citrus, apple, and red fruits, and discusses potential interactions, disadvantages, and advantages, as well as the chemical structures involved in interactions with cytochromes P-450, P-glycoprotein, and organic anion transporter polypeptide (OATP), responsible for sometimes dangerous changes in bioavailability or potential accumulation of drugs in the body. Full article
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