Spirocycles in Medicinal Chemistry

Dear Colleagues,

Spirocycles represent an emerging privileged platform for drug design. In contrast to traditional heterocycles frequently employed in drug discovery, spirocycles possess the right degree of conformational rigidity, high degree of saturation (expressed as fraction of sp³-hybridized atoms or F_sp3), and a pronounced three-dimensionality. The latter aspect makes spirocyclic scaffolds particularly suitable cores for finding an optimal projection of periphery appendages for interaction with biological targets. Given this, it is perhaps unsurprising that the frequency of employing spirocyclic motifs in designing biologically small molecules has been on the rise.

This special position of spirocycles in modern medicinal chemistry mandates that new efficient methods for assembling spirocyclic frameworks continue to be invented.

The new Special Issue aims to publish a collection of reviews as well as original research papers devoted to the synthetic strategies towards spirocycles as well as to drug-discovery applications of spirocycles in various therapeutic areas.

Prof. Dr. Mikhail Krasavin
Prof. Dr. Dmitry Dar’in
Guest Editors

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