Modern Trends of Biocatalysis in Organic Chemistry and Enzyme Engineering

Dear Colleagues,

With the depletion of non-renewable resources and the increase in environmental pollution, organic reactions, which produce a lot of organic solvent consumption, are considered to be environmentally unfriendly. As a practical and sustainable alternative to traditional organic reactions, biocatalysis exhibits its extremely advantages in selectivity and efficiency. Many classic C-C and C-X bond formation reactions could be efficiently catalyzed by biocatalysts, and which have been widely used in the synthesis of fine chemicals such as pharmaceuticals and their intermediates, nutritional additives, cosmetics, etc. Various solvents have been developed and used as the medium of enzymatic reactions, and various immobilization materials and methods have been developed to improve the stability of enzymes. Moreover, the increasing demands for efficient and versatile synthetic methods, combined with powerful new discoveries and engineering tools, have prompted innovations in biocatalysis, especially the development of new enzymes for precise transformations or "molecular editing". As a result, the past decade has witnessed an impressive expansion of biocatalysis.

This Special Issue on "Modern Trends of Biocatalysis in Organic Chemistry and Enzyme Engineering"aims to be an open forum where researchers share their achievements on enzyme engineering and its applications in organic synthesis. Contributions to this issue, in the form of both original research and review articles, may cover the enhancement of catalytic performance of enzymes including immobilization, chemical modification, rational design and directed evolution, applications of biocatalysts in organic synthesis, biocatalytic promiscuity, development and utilizations of green solvents for enzymatic reactions, enzymatic-chemical methods for the synthesis fine chmicals, multi-enzyme synergistic catalysis, photo-enzyme synergistic catalysis, and others.

Prof. Dr. Yi Hu
Dr. Gang Xu
Guest Editors

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