Discovery and Development of Anti-Cancer Drugs: From Signalling Pathways to Molecular Mechanisms

Dear Colleagues,

This Special Issue, entitled "Discovery and Development of Anti-Cancer Drugs: From Signalling Pathways to Molecular Mechanisms", aims to highlight groundbreaking advances in the understanding of cancer chemicobiology and the translation of these insights into novel therapeutic strategies. By bridging the gap between basic molecular research and drug development, this issue seeks to promote interdisciplinary collaboration among medicinal chemists, cancer biologists, and immunologists, and it will emphasize the mechanistic foundations that drive the discovery and optimization of targeted anti-cancer therapies.

The development of next-generation cancer therapies demands a deep understanding of the molecular circuitry that drives tumor progression and therapeutic resistance. The focus will be on unraveling key oncogenic signaling pathways, tumor microenvironmental interactions, and molecular determinants of drug sensitivity and resistance. Special attention will be given to the rational design of small molecules, biologics, and immunotherapies that target these pathways, as well as to novel approaches in preclinical modeling, biomarker identification, and clinical translation.

Prof. Dr. Leonardo Oliveira Reis
Prof. Dr. Lívia Bitencourt Pascoal
Guest Editors

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