Chiral Chemistry—from Molecules to Supramolecules

Dear Colleagues,

We are pleased to invite you to contribute to this Special Issue, which aims to explore the multi-scale nature of chirality. Chirality is a fundamental property of nature that plays a pivotal role across various disciplines, ranging from organic synthesis, biological recognition, and pharmaceutics to the design of advanced functional materials. While the asymmetric synthesis of small molecules remains a cornerstone of chemical research, the focus has increasingly expanded toward understanding how chiral information is transferred, amplified, and expressed in complex supramolecular architectures. Bridging the gap between individual molecular chirality and macroscopic supramolecular organization is essential for understanding the origin of homochirality and promoting the next generation of sensing, catalytic, and optoelectronic applications.

This Special Issue aims to provide a comprehensive platform for the dissemination of cutting-edge research that bridges the gap between molecular chirality and supramolecular assemblies. It seeks to highlight how precise molecular design influences self-assembly processes, leading to novel properties and functions. By connecting the fields of organic synthesis, supramolecular chemistry, and materials science, this Special Issue aligns with the scope of the journal, emphasizing the structural and functional evolution of chiral molecular systems. We are interested in contributions that not only report new chiral structures but also elucidate the mechanisms of chirality transfer and functional performance.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

• Asymmetric Synthesis and Catalysis: The development of novel methodologies for enantioselective synthesis and the design of efficient chiral catalysts and ligands.
• Supramolecular Chirality: Chiral self-assembly processes, mechanisms of chirality transfer and amplification, symmetry breaking, and the propagation of chirality from molecular to macroscopic levels.
• Chiral Materials: The synthesis and application of chiral metal–organic frameworks (MOFs), covalent organic frameworks (COFs), chiral polymers, chiral gel, etc.
• Chiral Recognition and Sensing: Host–guest chemistry, enantioselective sensing mechanisms, chiral discrimination, and resolution techniques.
• Chiral Optoelectronics: Circularly polarized luminescence (CPL)-active materials, chiroptical switches, and chiral photonic devices.

We look forward to receiving your contributions.

Dr. Chengshuo Shen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.