Immune Responses in Cryptosporidium parvum Infection

Dear Colleagues,

Cryptosporidiosis was initially recognized in compromised hosts, including patients with AIDS. Cryptosporidium species that infect humans are increasing recognized as major contributors to childhood diarrhea and malnutrition in low- and middle-income countries. In most people, the host response limits cryptosporidiosis to a self-limited or asymptomatic infection, and repeated infections gradually lead to resistance to reinfection. Initial studies on the host response to cryptosporidiosis focused on the CD4 T-cell memory and production of interferon gamma. Subsequent studies are increasingly revealing a complex network of innate and acquired immune responses to the parasite, with roles for innate and adapted lymphocytes, epithelial cells, and innate cells such as dendritic cells. This Special Issue of Microorganisms will focus on the host response to human cryptosporidiosis and the role of different aspects of the host response in controlling cryptosporidiosis.

Prof. Dr. A. Clinton White
Dr. Sara M. Dann
Guest Editors

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