Special Issue "Diverse Structures and Functions of Bacterial Effectors"
Deadline for manuscript submissions: closed (31 March 2021).
Bacterial infections are associated with some of the largest burdens to human health across the globe. Pathogenic bacteria have developed sophisticated mechanisms to secrete virulence proteins directly into animal and plant cells. Once inside their host, these effectors perform various functions that include the regulation of endosomal/apoptotic pathways, modulation of cytoskeleton structure, and evasion of host-immune responses. In order to carry out these diverse functions, many bacterial effectors have evolved to imitate endogenous host proteins, in both their subcellular targeting and specific activities. Whilst analysis of primary amino acid sequences and tertiary structures can sometimes elude to function, this is often not the case. This is because these bacterial proteins frequently mimic smaller subregions of host regulatory factors or use completely different structural elements to induce similar changes in host proteins. This Special Issue of Microorganisms will be dedicated to understanding the diversity in bacterial effector structures and functions during infection. This will include the following themes: structures of novel effectors; common structural motifs of effectors; specific functions of effectors in ecology and disease; challenges and tools in identifying effector functions and subcellular localization; role of moonlighting effector proteins during infection; and the practical applications of bacterial effector research in treating disease.Dr. James Garnett
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Virulence factor
- Moonlighting protein