Molecular Mechanisms of Mammalian Intra-Amniotic Infection
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 11
Special Issue Editors
Interests: bacterial virulence
Special Issues, Collections and Topics in MDPI journals
Interests: pathogenic and beneficial host-microbe interactions within the realms of medicine and behavior
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Among mammals, microbial invasion of the amniotic cavity resulting in intra-amniotic infection (IAI) often leads to pregnancy complications such as spontaneous preterm labor and chorioamnionitis, two maladies which are leading causes of neonatal and maternal morbidity and mortality, respectively. The principal sources of IAI agents are the ascension of microbes from the vagina through the cervix and hematogenous dissemination from the maternal mouth or intestine. A fundamental gap in current understanding is why, given the sheer diversity of microbes populating mammalian bodies, only a small subset of microbes consistently invades the amniotic cavity resulting in IAI. For this Special Issue, we encourage the submission of original observations and perspective essays addressing the identification and evaluation of the pathogenic mechanisms by which microbes (1) compromise the integrity of mammalian fetal membranes, (2) capitalize on opportunities afforded by other membrane-compromising microbes to preferentially grow and replicate within the ruptured amniotic cavity, and/or (3) successfully invade and proliferate within the amniotic cavity in the absence of ruptured fetal membranes. The overarching aim is to synthesize current understanding and forge a clear hypothesis-driven and experimentally focused path forward in mitigating the occurrence and detrimental outcomes of IAI.
The Special Issue entitled Molecular Mechanisms of Mammalian Intra-Amniotic Infection aims to present recent research on any aspect of intra-amniotic infection. Some of its focal points include, but are not limited to, the following:
- Microbes that compromise the integrity of mammalian fetal membranes.
- Microbe–microbe interactions that potentiate intra-amniotic infections.
- Mechanisms of microbial dissemination leading to intra-amniotic infection.
Reviews, original research, and communications are welcome.
Dr. Matthew Jackson
Dr. Kevin Theis
Guest Editors
Manuscript Submission Information
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Keywords
- intra-amniotic infections
- microbes
- pathogenic mechanisms
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