Mechanisms of Mycobacteria Drug Escape – an Opportunity for Innovative Antimycobacterial Drug Development
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 1703
Special Issue Editor
Special Issue Information
Dear Colleagues,
Tuberculosis (TB) caused mainly by Mycobacterium tuberculosis, which represents the second largest cause of death, after COVID-19, from a single infectious agent. The current treatment regimen lasts months and uses four anti-TB drugs. Furthermore, the emergence of multidrug-resistant strains is a major concern.
Infected patients can either present with TB or be latently infected. M. tuberculosis can be detected either intracellularly, in the macrophage, granuloma, or extracellularly, in necrotic lesions.
Due to metabolic changes, the ability of M. tuberculosis to resist or adapt and persist to its stress environment is one of the main reasons that explains the difficulty of achieving its eradication and cure.
This Special Issue will explore mycobacterial drug resistance and tolerance mechanisms and highlight new anti-TB target candidates.
Dr. Véronique Fontaine
Guest Editor
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Keywords
- Mycobacterium
- drug resistance
- drug tolerance
- metabolic adaptation
- biofilm
- anti-TB drug development
- anti-TB drug target
- mycobacterial cell wall
- efflux pumps
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